All Phenotypes Il12a<tm1Cab> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il12a^tm1Cab
targeted mutation 1, Christine A Biron
MGI:2388729

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il12a^tm1Cab/Il12a^tm1Cab	B6.129S4-Il12a^tm1Cab	MGI:3813922
hm2	Il12a^tm1Cab/Il12a^tm1Cab	involves: 129S4/SvJae * C57BL/6	MGI:3813911
cx3	Il12a^tm1Cab/Il12a^tm1Cab Il23a^tm1.1Thak/Il23a^tm1.1Thak	B6.Cg-Il12a^tm1Cab Il23a^tm1.1Thak	MGI:3830543

Allelic Composition	Il12a^tm1Cab/Il12a^tm1Cab
Genetic Background	B6.129S4-Il12a^tm1Cab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Cab mutation (0 available); any Il12a mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell physiology ( J:79552 )

• there is 4-fold less NK cells in MCMV infected mice that are producing IFN-gamma than in controls

decreased circulating interferon-gamma level ( J:79552 )

• 1.5 days after MCMV infection, IFN-gamma levels in serum are about 40-fold lower than in controls

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:79552 )

• 1.5 days after MCMV infection, IFN-gamma levels in serum are about 40-fold lower than in controls

hematopoietic system

abnormal NK cell physiology ( J:79552 )

• there is 4-fold less NK cells in MCMV infected mice that are producing IFN-gamma than in controls

Allelic Composition	Il12a^tm1Cab/Il12a^tm1Cab
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Cab mutation (0 available); any Il12a mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interferon-gamma level ( J:54482 )

• IFN-gamma levels are not detectable in serum 36 hours after LCMV infection

decreased circulating interleukin-12 level ( J:54482 )

• IL-12 heterodimer levels are absent from serum 2.5- and 5- hours after LPS injection or 36 hours after LCMV infection

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:54482 )

• IFN-gamma levels are not detectable in serum 36 hours after LCMV infection

decreased circulating interleukin-12 level ( J:54482 )

• IL-12 heterodimer levels are absent from serum 2.5- and 5- hours after LPS injection or 36 hours after LCMV infection

Allelic Composition	Il12a^tm1Cab/Il12a^tm1Cab Il23a^tm1.1Thak/Il23a^tm1.1Thak
Genetic Background	B6.Cg-Il12a^tm1Cab Il23a^tm1.1Thak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Cab mutation (0 available); any Il12a mutation (33 available)
Il23a^tm1.1Thak mutation (0 available); any Il23a mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:143970 )

• mice are susceptible to EAE when they are recipients of activated CD4⁺ T cells isolated from MOG-immunized mice with slightly less inflammation occurring in the cervical spinal cord

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23