All Phenotypes Gdi1<tm1Toni> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Gdi1^tm1Toni/Y	B6N.129S7-Gdi1^tm1Toni	MGI:3833428
ot2	Gdi1^tm1Toni/Y	either: B6.129S7-Gdi1^tm1Toni or (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * DBA/2)	MGI:3833426

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal cued conditioning behavior ( J:142806 )

• trace fear conditioning response is impaired when the intertraining interval is 15 or 26 min but not when the intertraining interval is 37 or 60 min

abnormal spatial working memory ( J:142806 )

• poor performance in an 8 arm radial maze

• performance is poor compared to controls when mice are trained in a 4 arm maze and tested 24 h later in an 8 arm maze but not when testing occurs 48 h after training

nervous system

abnormal synaptic vesicle number ( J:142806 )

• at P23 and P90 severe depletion of synaptic vesicles is seen in synaptic terminals in the stratum radiatum of the CA1 region of the hippocampus

abnormal excitatory postsynaptic potential ( J:142806 )

• display an increased facilitation during the initial phase to tetanic stimulation

• at the end of the train synapses reach a milder depression plateau

abnormal synaptic glutamate release ( J:142806 )

• decrease in the depression in glutamate release following multiple pulses of KCL

decreased synaptic glutamate release ( J:142806 )

• glutamate release evoked by 15 nm KCL is reduced

enhanced paired-pulse facilitation ( J:142806 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-syndromic X-linked intellectual disability		DOID:0050776	OMIM:300716 OMIM:PS309530	J:142806

Allelic Composition	Gdi1^tm1Toni/Y
Genetic Background	either: B6.129S7-Gdi1^tm1Toni or (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * DBA/2)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdi1^tm1Toni mutation (0 available); any Gdi1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal cued conditioning behavior ( J:79454 )

• impaired trace fear conditioning

• however, delay fear conditioning behavior is similar to controls

abnormal spatial working memory ( J:79454 )

• in a radial maze after training mice perform just barely above the chance level unlike wild-type controls which after training show nearly perfect performance

decreased aggression towards mice ( J:79454 )

• decrease in aggression in a resident intruder assay

• mice spend more time sniffing the snout end of intruders compared to controls

nervous system

abnormal hippocampus CA3 region morphology ( J:79454 )

• in the hilar region of CA3 pyramidal cells appear more scattered

abnormal hippocampal mossy fiber morphology ( J:79454 )

• increase in the frequency of trilamination of suprapyramidal mossy fibers

abnormal excitatory postsynaptic potential ( J:79454 )

• significant depression of the slope of the field EPSP in the first 5 minutes post tetanus

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:79454 )

N	• despite abnormalities in aggressive behavior, serum testosterone levels are similar to controls

taste/olfaction

taste/olfaction phenotype ( J:79454 )

N	• despite abnormalities in aggressive behavior, no abnormalities in olfaction are detected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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