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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sagtm1Jnc
targeted mutation 1, Jeannie Chen
MGI:2388373
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sagtm1Jnc/Sagtm1Jnc involves: 129S/SvEv MGI:2671969
cx2
Sagtm1Jnc/Sagtm1Jnc
Rhotm1Shda/Rhotm1Shda
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3710687
cx3
Arr3tm1Chcr/Arr3tm1Chcr
Sagtm1Jnc/Sagtm1Jnc
involves: 129S/SvEv * C57BL/6 MGI:3810255


Genotype
MGI:2671969
hm1
Allelic
Composition
Sagtm1Jnc/Sagtm1Jnc
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sagtm1Jnc mutation (9 available); any Sag mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice exhibit normal cone electrophysiology
• the rod outer segment is disorganized and 25% shorter than in wild-type mice
• however, raising mice in darkness reduces the effect
• rods exhibit an abnormal falling phase of the flash response compared to in wild-type mice (J:43294)
• recovery from flash response is prolonged in the final phase unlike wild type mice (J:43294)
• however, response to light adaptation is normal (J:43294)
• slow phase of the dim-flash response is 10-fold longer than in the Arrb1tm1Jnc Rhotm1Shda double homozygotes (J:120882)
• prolonged decay of slow-phase response is associated with increased meta-II decay (J:120882)

nervous system
• the rod outer segment is disorganized and 25% shorter than in wild-type mice
• however, raising mice in darkness reduces the effect




Genotype
MGI:3710687
cx2
Allelic
Composition
Sagtm1Jnc/Sagtm1Jnc
Rhotm1Shda/Rhotm1Shda
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Shda mutation (1 available); any Rho mutation (38 available)
Sagtm1Jnc mutation (9 available); any Sag mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• accelerated meta-II decay




Genotype
MGI:3810255
cx3
Allelic
Composition
Arr3tm1Chcr/Arr3tm1Chcr
Sagtm1Jnc/Sagtm1Jnc
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arr3tm1Chcr mutation (0 available); any Arr3 mutation (10 available)
Sagtm1Jnc mutation (9 available); any Sag mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• cones exhibit a greatly slowed recovery from strong flashes compared to wild-type cones
• the amplitude of slow tails of recovery are increased compared to in wild-type mice
• S- and M-cone opsin driven dim-flash responses exhibit slow tail in recovery unlike wild-type mice
• however, the peak time of dim-flash response is normal





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory