Mouse Genome Informatics
hm1
    Mat1atm1Jmm/Mat1atm1Jmm
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Liver histology from 8 month old Mat1atm1Jmm/Mat1atm1Jmm mice fed a normal diet

homeostasis/metabolism
• plasma methionine levels elevated 776%

liver/biliary system
• significantly increased at 3 months although the liver was histologically normal
• choline deficient diet causes severe macrovesicular steatosis in the liver
• severe macrovesicular steatosis in the liver in 8 month old mice on a normal diet
• levels of methionine metabolites were reduced in the liver
• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic

immune system
• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic

Mouse Models of Human Disease
OMIM IDRef(s)
Methionine Adenosyltransferase Deficiency 250850 J:69408