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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mat1atm1Jmm
targeted mutation 1, Jose M Mato
MGI:2388143
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mat1atm1Jmm/Mat1atm1Jmm involves: 129/Sv * C57BL/6 MGI:3579853


Genotype
MGI:3579853
hm1
Allelic
Composition
Mat1atm1Jmm/Mat1atm1Jmm
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mat1atm1Jmm mutation (0 available); any Mat1a mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Liver histology from 8 month old Mat1atm1Jmm/Mat1atm1Jmm mice fed a normal diet

homeostasis/metabolism
• plasma methionine levels elevated 776%

liver/biliary system
• significantly increased at 3 months although the liver was histologically normal
• choline deficient diet causes severe macrovesicular steatosis in the liver
• severe macrovesicular steatosis in the liver in 8 month old mice on a normal diet
• levels of methionine metabolites were reduced in the liver
• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic

immune system
• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic

Mouse Models of Human Disease
OMIM ID Ref(s)
Methionine Adenosyltransferase Deficiency 250850 J:69408





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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory