Mouse Genome Informatics
hm1
     Mat1atm1Jmm/Mat1atm1Jmm
involves: 129/Sv * C57BL/6
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype

Liver histology from 8 month old Mat1atm1Jmm/Mat1atm1Jmm mice fed a normal diet

homeostasis/metabolism
abnormal circulating amino acid level ( J:69408 )
• plasma methionine levels elevated 776%

liver/biliary system
increased liver weight ( J:69408 )
• significantly increased at 3 months although the liver was histologically normal
hepatic steatosis ( J:69408 )
• choline deficient diet causes severe macrovesicular steatosis in the liver
• severe macrovesicular steatosis in the liver in 8 month old mice on a normal diet
abnormal liver physiology ( J:69408 )
• levels of methionine metabolites were reduced in the liver
liver inflammation ( J:69408 )
• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic

immune system
liver inflammation ( J:69408 )
• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic

Mouse Models of Human Disease
 OMIM IDRef(s)
Methionine Adenosyltransferase Deficiency 250850 J:69408