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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc31a1tm1Djt
targeted mutation 1, Dennis J Thiele
MGI:2388121
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc31a1tm1Djt/Slc31a1tm1Djt involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3771159
ht2
Slc31a1tm1Djt/Slc31a1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3771160


Genotype
MGI:3771159
hm1
Allelic
Composition
Slc31a1tm1Djt/Slc31a1tm1Djt
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc31a1tm1Djt mutation (0 available); any Slc31a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E7.5, mesoderm is poorly developed
• at E9.5, mesenchyme cell formation is severely diminished
• at E7.5, neural ectoderm is poorly developed

growth/size/body

nervous system
• at E7.5, neural ectoderm is poorly developed




Genotype
MGI:3771160
ht2
Allelic
Composition
Slc31a1tm1Djt/Slc31a1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc31a1tm1Djt mutation (0 available); any Slc31a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• copper levels in the spleen and brain are decreased (spleen, 0.6+/-0.1 compared to 1.0+/-0.4 in wild-type mice; brain, 1.7+/-0.2 compared to 3.2+/-0.1 in wild-type mice)
• iron levels in the liver are decreased (67.8+/-9.0 compared to 81.2+/-10.6 in wild-type mice)

liver/biliary system
• iron levels in the liver are decreased (67.8+/-9.0 compared to 81.2+/-10.6 in wild-type mice)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory