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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou3f1tm2.1Mejr
targeted mutation 2.1, Dies Meijer
MGI:2387953
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pou3f1tm2.1Mejr/Pou3f1tm2.1Mejr involves: 129P2/OlaHsd * FVB MGI:3834161
ht2
 		Pou3f1tm1Mejr/Pou3f1tm2.1Mejr involves: 129P2/OlaHsd MGI:4359762
cn3
 		Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Pou3f2tm1Mejr/Pou3f2tm1Mejr
Tg(Dhh-cre)1Mejr/0 		involves: 129P2/OlaHsd * FVB/N MGI:4359761


Genotype
MGI:3834161
hm1
Allelic
Composition		 Pou3f1tm2.1Mejr/Pou3f1tm2.1Mejr
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1tm2.1Mejr mutation (0 available); any Pou3f1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:78939 )
N
• unlike mice homozygous for a null allele, mice are viable

nervous system
abnormal myelination ( J:78939 )
• developmental delay in peripheral nerve myelination with most Schwann cells remaining in a promyelin configuration during the week of life
• initiation of myelination by most Schwann cells occurs between P16 and P32 compared to P8 in heterozygous controls
• myelination is also delayed during nerve regeneration following crush injury of the sciatic nerve

respiratory system
respiratory system phenotype ( J:78939 )
N
• unlike mice homozygous for a null allele, mice do not develop respiratory distress




Genotype
MGI:4359762
ht2
Allelic
Composition		 Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1tm1Mejr mutation (0 available); any Pou3f1 mutation (14 available)
Pou3f1tm2.1Mejr mutation (0 available); any Pou3f1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Schwann cell morphology ( J:83739 )
• at P16, majority of Schwann cells are arrested at promyelin stage of differentiation




Genotype
MGI:4359761
cn3
Allelic
Composition		 Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Pou3f2tm1Mejr/Pou3f2tm1Mejr
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1tm1Mejr mutation (0 available); any Pou3f1 mutation (14 available)
Pou3f1tm2.1Mejr mutation (0 available); any Pou3f1 mutation (14 available)
Pou3f2tm1Mejr mutation (0 available); any Pou3f2 mutation (19 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:83739 )
• at P56 and P120 (about 55% and 25%), respectively, of nerves are abnormal with many promyelin configurations
abnormal myelination ( J:83739 )
• at P16 nerves contain many promyelin configurations in contrast to wild type and heterozygotes in which >90% of large-caliber axons are myelinated
• at P56 and P120, abnormal axons are thinly myelinated resembling wild-type nerves during the first postnatal week




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory