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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Odc1tm1Jlc
targeted mutation 1, John L Cleveland
MGI:2387837
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Odc1tm1Jlc/Odc1tm1Jlc involves: 129S1/Sv MGI:2669243
ht2
 		Odc1tm1Jlc/Odc1+ involves: 129S1/Sv MGI:2669244


Genotype
MGI:2669243
hm1
Allelic
Composition		 Odc1tm1Jlc/Odc1tm1Jlc
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Odc1tm1Jlc mutation (0 available); any Odc1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:71462 )
• embryos develop normally to the blastocyst stage and implant but die shortly thereafter, before the onset of gastrulation

embryo
abnormal inner cell mass apoptosis ( J:71462 )
• E3.5 embryos show an increase in TUNEL-positive cells in the inner cell mass

cellular
abnormal inner cell mass apoptosis ( J:71462 )
• E3.5 embryos show an increase in TUNEL-positive cells in the inner cell mass




Genotype
MGI:2669244
ht2
Allelic
Composition		 Odc1tm1Jlc/Odc1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Odc1tm1Jlc mutation (0 available); any Odc1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory