Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Ack mutation
(0 available);
any
Pthlh mutation
(19 available)
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tmem163Tg(ACTB-cre)2Mrt mutation
(3 available);
any
Tmem163 mutation
(35 available)
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mortality/aging
skeleton
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• the chondrocyte columns are disorganized and premature differentiation to the hypertrophic state occurs
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• the chondrocyte columns are disorganized
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• premature and inappropriate ossification throughout the endochondral skeleton
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respiratory system
growth/size/body
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• shortening of the mandible results in protrusion of the tongue
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craniofacial
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• shortening of the mandible results in protrusion of the tongue
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digestive/alimentary system
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• shortening of the mandible results in protrusion of the tongue
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Ack mutation
(0 available);
any
Pthlh mutation
(19 available)
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(LGB-cre)74Acl mutation
(2 available)
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skeleton
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• the osteoclast surface/bone surface ratio and number of osteoclasts per bone perimeter are reduced
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• the reduced rate of bone turnover during lactation preserves bone mass so that on day 12 of lactation mutants have nearly 20% more bone mass than controls
• however, bone mass is similar to controls at the start of lactation
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• bone formation rate per tissue volume is reduced
• however, osteoblast numbers and surface appear normal
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homeostasis/metabolism
reproductive system
N |
• no functional defects in lactation, abnormalities in mammary gland morphology, or decrease in litter size or growth of pups is seen
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renal/urinary system
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• urinary excretion of cAMP is decreased to 19.3 +/- 0.8 ug/mmol creatinine compared to 33.9 +/- 0.6 ug/mmol creatinine in controls
• urinary levels of C-telopeptides of type I collagen are significantly lower (3.98 +/- 0.82 ug/mmol creatinine versus 6.83 +/- 0.29 ug/mmol creatinine in controls)
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hematopoietic system
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• the osteoclast surface/bone surface ratio and number of osteoclasts per bone perimeter are reduced
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immune system
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• the osteoclast surface/bone surface ratio and number of osteoclasts per bone perimeter are reduced
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1.1Ack mutation
(0 available);
any
Pthlh mutation
(19 available)
Pthlhtm1Ack mutation
(0 available);
any
Pthlh mutation
(19 available)
Tmem163Tg(ACTB-cre)2Mrt mutation
(3 available);
any
Tmem163 mutation
(35 available)
|
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mortality/aging
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• phenotype is stated to be identical to that of conditional mutants with a Pthlhtm1Hmk allele in place of the Pthlhtm1.1Ack allele; however no data is presented in J:69396
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skeleton
respiratory system
growth/size/body
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• shortening of the mandible results in protrusion of the tongue
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craniofacial
|
• shortening of the mandible results in protrusion of the tongue
|
digestive/alimentary system
|
• shortening of the mandible results in protrusion of the tongue
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Ack mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Col1a1-cre)1Ack mutation
(0 available)
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skeleton
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• the number and surface of osteoclasts is reduced by 43% and 52%, respectively
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• long bones appear less radiopaque and bone mineral density is decreased
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• osteoblast number and surface are decreased by 55% and 60%, respectively and osteoid volume is decreased by 75%
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• the percentage of apoptotic osteoblasts/osteocytes is increased more than 8-fold compared to controls
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• the bone marrow space is increased with only scattered thin spicules of trabecular bone
trabecular number and thickness are decreased and trabecular separation is increased in the distal femur and proximal tibia
• however, there is no increase in bone marrow adiposity unlike Pthlh null homozygotes
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• the mineral apposition rate is decreased by 45% and 60% in the tibial cortex and trabeculae, respectively
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hematopoietic system
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• the number and surface of osteoclasts is reduced by 43% and 52%, respectively
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immune system
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• the number and surface of osteoclasts is reduced by 43% and 52%, respectively
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