Phenotypes associated with this allele

• Allele Symbol: Dpt^tm1Hsh
• Allele Name: targeted mutation 1, Hiroshi Shinkai
• Allele ID: MGI:2387341
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpt^tm1Hsh/Dpt^tm1Hsh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2450163

Genotype
MGI:2450163

hm1

• Allelic Composition: Dpt^tm1Hsh/Dpt^tm1Hsh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:78845 )

• increased thickness of subcutaneous adipose tissue

vision/eye

vision/eye phenotype ( J:112233 )

N • normal corneal epithelium

decreased cornea thickness ( J:112233 )

• corneal thickness is significantly reduced

decreased corneal stroma thickness ( J:112233 )

abnormal corneal stroma morphology ( J:112233 )

abnormal cornea posterior stroma morphology ( J:112233 )

• lamellae are less well defined

• increased interfibrillar spacing

integument

abnormal cutaneous collagen fibril morphology ( J:78845 )

• significant decrease in collagen in the skin although rate of synthesis seems normal

• increased collagen fibril diameter and contours are irregular

• bundles of collagen fibrils are wavy and tortuous but fibrils are arranged in parallel

thin dermal layer ( J:78845 )

• decreased thickness

loose skin ( J:78845 )

abnormal skin condition ( J:78845 )

abnormal skin tensile strength ( J:78845 )

• increased elasticity as determined as a decrease in the initial elastic modulus during tensile strength tests