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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fostm1Mxu
targeted mutation 1, Ming Xu
MGI:2387304
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fostm1Mxu/Fostm1Mxu
Tg(Drd1-cre)120Mxu/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J MGI:3814565
cn2
Fostm1Mxu/Fostm1Mxu
Tg(Camk2a-cre)T50Stl/0
involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:3814562


Genotype
MGI:3814565
cn1
Allelic
Composition
Fostm1Mxu/Fostm1Mxu
Tg(Drd1-cre)120Mxu/0
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm1Mxu mutation (1 available); any Fos mutation (32 available)
Tg(Drd1-cre)120Mxu mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• repeated 20 mg/kg cocaine treatment does not induce behavioral sensitization in mutants, in contrast to wild-type; sensitized grooming behavior develops to similar extent in mutant and wild-type animals
• mutants exhibit more persistent memory for reinforcing effects of cocaine than wild-type mice
• cocaine-induced conditioned place preference behavior does not extinguish until 22 days of training compared to 12 (and 16) days of training in wild-type
• 20 mg/kg cocaine treatment induces rearing in controls and mutants, but mutants show lower activity than controls; with repeated injections, wild-type mice develop sensitized rearing but mutants do not

nervous system
• repeated cocaine injections increase dendritic spine density on medium spiny neurons in the nucleus accumbens and caudate putamen of wild-type mice, but mutant brains show lower spine densities
• repeated cocaine injections increase the number of dendrites in the cortex of wild-type mice, but mutants have significantly lower dendritic number




Genotype
MGI:3814562
cn2
Allelic
Composition
Fostm1Mxu/Fostm1Mxu
Tg(Camk2a-cre)T50Stl/0
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm1Mxu mutation (1 available); any Fos mutation (32 available)
Tg(Camk2a-cre)T50Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• population spike amplitude evoked by minimal stimulation intensity is significantly larger in hippocampal mutant slices compared to wild-type slices with a large increase in cellular excitability and a larger maximal response
• >60% of slices show epileptiform activity following low intensity stimulation compared to <40% of wild-type
• very low concentration kainic acid (KA) stimulation of hippocampal slices produces maximal CA3 population spike amplitude and higher concentrations induces severe epileptiform activity, reducing amplitude of the population response





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory