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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Rag2-Igb)1Mnz
transgene insertion 1, Michel C Nussenzweig
MGI:2387028
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv MGI:2653667
cx2
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv * C57BL/6 MGI:4453800
cx3
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:4453802
cx4
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi MGI:4453801


Genotype
MGI:2653667
cx1
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:78601 )
• B cells fail to proceed past the pre-B cell stage and do not differentiate into IgM+ immature B cells
abnormal pre-B cell morphology ( J:78601 )
• pre-B cells exhibit increased apoptosis

immune system
arrested B cell differentiation ( J:78601 )
• B cells fail to proceed past the pre-B cell stage and do not differentiate into IgM+ immature B cells
abnormal pre-B cell morphology ( J:78601 )
• pre-B cells exhibit increased apoptosis




Genotype
MGI:4453800
cx2
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:78601 )
• increase in apoptosis of immature B cells
arrested B cell differentiation ( J:78601 )
• B cells fail to develop beyond the IgMlow immature B cell stage and no mature recirculating CD25-IgMhigh B cells are seen

immune system
abnormal immature B cell morphology ( J:78601 )
• increase in apoptosis of immature B cells
arrested B cell differentiation ( J:78601 )
• B cells fail to develop beyond the IgMlow immature B cell stage and no mature recirculating CD25-IgMhigh B cells are seen




Genotype
MGI:4453802
cx3
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(BCL2)22Wehi mutation (2 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues immature B cell apoptosis but immature B cell differentiation beyond the IgMlow immature B cell stage is still impaired and no mature recirculating CD25-IgMhigh B cells are seen

immune system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues immature B cell apoptosis but immature B cell differentiation beyond the IgMlow immature B cell stage is still impaired and no mature recirculating CD25-IgMhigh B cells are seen




Genotype
MGI:4453801
cx4
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(BCL2)22Wehi mutation (2 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired

immune system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory