Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Hsa mutation
(0 available);
any
Kcnq2 mutation
(47 available)
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mortality/aging
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• homozygous null mice died within 1 day after birth; newborn pups appeared grossly normal, and some were able to survive for a few hours after birth
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respiratory system
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• pathological analysis revealed a decrease in alveolar expansion suggesting that homozygous null pups died of pulmonary atelectasis
• homozygous mutant pups exhibited modest or severe atelectasis and a thickened alveolar epithelial layer compared with normal alveoli maturation in wild-type pups
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nervous system
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N |
• homozygous null mice displayed no abnormalities in brain development or in electrocardiograms
• in addition, mutant pups exhibited no signs of seizure or other physical manifestations while they were alive
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Allelic
Composition |
Kcnq2tm1Hsa/Kcnq2+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Hsa mutation
(0 available);
any
Kcnq2 mutation
(47 available)
|
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behavior/neurological
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N |
• mice were behaviorally indistinguishable from wild-type littermates and do not appear to display epileptic behaviors
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• at approximately 3 weeks of age, analysis of basal electroencephalograph recordings indicated no differences between wild-type and heterozygous null mice: pentylenetetrazole (PTZ) induced seizures in both genotypes, resulting in several presageful sharp waves followed by an explosion of seizures
• the PTZ-induced seizure was a generalized seizure, which simultaneously occurred in all regions of the cerebrum in both wild-type and heterozygous null mice
• however, wild-type mice required a greater number of PTZ injections to induce seizures than heterozygous null mice, suggesting that young heterozygotess are hypersensitive to PTZ-induced seizures
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nervous system
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• at approximately 3 weeks of age, analysis of basal electroencephalograph recordings indicated no differences between wild-type and heterozygous null mice: pentylenetetrazole (PTZ) induced seizures in both genotypes, resulting in several presageful sharp waves followed by an explosion of seizures
• the PTZ-induced seizure was a generalized seizure, which simultaneously occurred in all regions of the cerebrum in both wild-type and heterozygous null mice
• however, wild-type mice required a greater number of PTZ injections to induce seizures than heterozygous null mice, suggesting that young heterozygotess are hypersensitive to PTZ-induced seizures
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reproductive system
Analysis Tools