Phenotypes associated with this allele
Allelic
Composition |
Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
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Genetic
Background |
either: (involves: 129S4/SvJaeSor * BALB/c ) or (involves: 129S4/SvJaeSor * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Bodd mutation
(0 available);
any
Ltb4r1 mutation
(20 available)
|
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immune system
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• in a K/BxN serum transfer model, mice do not exhibit any inflammation or bone erosion in joints unlike similarly treated wild-type mice
|
skeleton
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• in a K/BxN serum transfer model, mice do not exhibit any inflammation or bone erosion in joints unlike similarly treated wild-type mice
|
cellular
hematopoietic system
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Bodd mutation
(0 available);
any
Ltb4r1 mutation
(20 available)
|
|
|
immune system
|
|
• following treatment with collagen to induce arthritis, mice exhibit no evidence of immune infiltration, pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice
• however, mice do produce antibodies against collagen type II
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skeleton
|
|
• following treatment with collagen to induce arthritis, mice exhibit no evidence of immune infiltration, pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice
• however, mice do produce antibodies against collagen type II
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Bodd mutation
(0 available);
any
Ltb4r1 mutation
(20 available)
|
|
|
immune system
|
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• upon adoptive transfer of IRBP1-20-specific T cells from wild-type B6 donors to wild-type and Ltbr4-deficient recipients, wild-type mice develop chronic and severe uveitis, whereas mutant recipients show only mild and transient clinical disease
• adoptive transfer of IRBP1-20-specific Ltbr4-deficient mice to B6 recipients results in moderate uveitis, while transfer to Ltbr4-deficient recipients do not develop disease
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Analysis Tools