All Phenotypes Hfe<tm1.1Nca> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hfe^tm1.1Nca
targeted mutation 1.1, Nancy C Andrews
MGI:2385350

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hfe^tm1.1Nca/Hfe^tm1.1Nca	involves: 129S6/SvEvTac	MGI:2655512
hm2	Hfe^tm1.1Nca/Hfe^tm1.1Nca	involves: 129S6/SvEvTac * C57BL/6J	MGI:2655513
hm3	Hfe^tm1.1Nca/Hfe^tm1.1Nca	Not Specified	MGI:2655503
cx4	Hfe^tm1.1Nca/Hfe^tm1.1Nca Tfrc^tm1Nca/Tfrc⁺	Not Specified	MGI:2655504

Allelic Composition	Hfe^tm1.1Nca/Hfe^tm1.1Nca
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Nca mutation (1 available); any Hfe mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:78536 )

• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background

• less iron accumulation than in Hfe^tm2Nca homozygous mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:78536

Allelic Composition	Hfe^tm1.1Nca/Hfe^tm1.1Nca
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Nca mutation (1 available); any Hfe mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:78536 )

• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background

• less iron accumulation than in Hfe^tm2Nca homozygous mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:78536

Allelic Composition	Hfe^tm1.1Nca/Hfe^tm1.1Nca
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Nca mutation (1 available); any Hfe mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased liver iron level ( J:62112 )

liver/biliary system

increased liver iron level ( J:62112 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:62112

Allelic Composition	Hfe^tm1.1Nca/Hfe^tm1.1Nca Tfrc^tm1Nca/Tfrc⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Nca mutation (1 available); any Hfe mutation (34 available)
Tfrc^tm1Nca mutation (1 available); any Tfrc mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased liver iron level ( J:62112 )

• greater hepatic iron loading than than the single Hfe^tm1.1Nca homozygous mutant

liver/biliary system

increased liver iron level ( J:62112 )

• greater hepatic iron loading than than the single Hfe^tm1.1Nca homozygous mutant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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