Mouse Genome Informatics
tg1
    Tg(UPII-SV40T)29Xrw/0
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• micrometastases are seen in the pelvic lymph nodes and lingular lobe of the liver
• mutants succumb to bladder cancer at 5 months of age
• all mice examined at 1-2 months of age exhibit only bladder carcinoma in situ (CIS) changes, but by 5 months of age, invasive and metastatic transitional cell carcinoma (TCC) is seen
• mutants develop a palpable abdominal tumor at 5 months of age, with histology identifying it as a poorly differentiated transitional cell carcinoma (TCC)

Mouse Models of Human Disease
OMIM IDRef(s)
Bladder Cancer 109800 J:56305