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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(UPII-SV40T)29Xrw
transgene insertion 29, Xue-Ru Wu
MGI:2384606
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(UPII-SV40T)29Xrw/0 involves: FVB/N MGI:5141747


Genotype
MGI:5141747
tg1
Allelic
Composition
Tg(UPII-SV40T)29Xrw/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mutants succumb to bladder cancer at 5 months of age
• all mice examined at 1-2 months of age exhibit only bladder carcinoma in situ (CIS) changes, but by 5 months of age, invasive and metastatic transitional cell carcinoma (TCC) is seen
• mutants develop a palpable abdominal tumor at 5 months of age, with histology identifying it as a poorly differentiated transitional cell carcinoma (TCC)

neoplasm
• micrometastases are seen in the pelvic lymph nodes and lingular lobe of the liver
• mutants succumb to bladder cancer at 5 months of age
• all mice examined at 1-2 months of age exhibit only bladder carcinoma in situ (CIS) changes, but by 5 months of age, invasive and metastatic transitional cell carcinoma (TCC) is seen
• mutants develop a palpable abdominal tumor at 5 months of age, with histology identifying it as a poorly differentiated transitional cell carcinoma (TCC)

Mouse Models of Human Disease
OMIM ID Ref(s)
Bladder Cancer 109800 J:56305





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory