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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-DMatm1Doi
targeted mutation 1, Christophe Benoist and Diane Mathis
MGI:2384509
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2-DMatm1Doi/H2-DMatm1Doi involves: 129S2/SvPas * C57BL/6 MGI:2386163
cx2
 		Cd74tm1Doi/Cd74tm1Doi
H2-DMatm1Doi/H2-DMatm1Doi 		involves: 129S2/SvPas * C57BL/6 MGI:2386166


Genotype
MGI:2386163
hm1
Allelic
Composition		 H2-DMatm1Doi/H2-DMatm1Doi
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-DMatm1Doi mutation (1 available); any H2-DMa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:31624 )
N
• positive selection of CD4+ T cells effective, yielding large and broad repertoire
abnormal professional antigen presenting cell physiology ( J:31624 )
• antigen presenting cells (APCs) had defective protein and peptide presentation




Genotype
MGI:2386166
cx2
Allelic
Composition		 Cd74tm1Doi/Cd74tm1Doi
H2-DMatm1Doi/H2-DMatm1Doi
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Doi mutation (1 available); any Cd74 mutation (33 available)
H2-DMatm1Doi mutation (1 available); any H2-DMa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:42482 )
• significant mortality after a few weeks of age

growth/size/body
decreased body size ( J:42482 )
• showed runting

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:42482 )
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
increased CD8-positive, alpha-beta T cell number ( J:42482 )
• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population

immune system
decreased CD4-positive, alpha-beta T cell number ( J:42482 )
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
increased CD8-positive, alpha-beta T cell number ( J:42482 )
• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population
abnormal professional antigen presenting cell physiology ( J:42482 )
• antigen presenting cells (APCs) had defective protein and peptide presentation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory