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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2-DMatm1Doi
targeted mutation 1, Christophe Benoist and Diane Mathis
MGI:2384509
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2-DMatm1Doi/H2-DMatm1Doi involves: 129S2/SvPas * C57BL/6 MGI:2386163
cx2
Cd74tm1Doi/Cd74tm1Doi
H2-DMatm1Doi/H2-DMatm1Doi
involves: 129S2/SvPas * C57BL/6 MGI:2386166


Genotype
MGI:2386163
hm1
Allelic
Composition
H2-DMatm1Doi/H2-DMatm1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-DMatm1Doi mutation (1 available); any H2-DMa mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• positive selection of CD4+ T cells effective, yielding large and broad repertoire
• antigen presenting cells (APCs) had defective protein and peptide presentation




Genotype
MGI:2386166
cx2
Allelic
Composition
Cd74tm1Doi/Cd74tm1Doi
H2-DMatm1Doi/H2-DMatm1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Doi mutation (1 available); any Cd74 mutation (21 available)
H2-DMatm1Doi mutation (1 available); any H2-DMa mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• significant mortality after a few weeks of age

growth/size/body
• showed runting

hematopoietic system
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population

immune system
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population
• antigen presenting cells (APCs) had defective protein and peptide presentation





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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory