Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F11tm1Gjb mutation
(1 available);
any
F11 mutation
(53 available)
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nervous system
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• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice
• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected
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• following transient cerebral ischemia, infarct size is reduced (27+/-24 mm3 compared to 46+/-21 mm3 in wild-type mice)
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F11tm1Gjb mutation
(1 available);
any
F11 mutation
(53 available)
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nervous system
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• after transient middle cerebral artery occlusion, the volume of infarcted brain is less than in controls
• reduced fibrin formation in ischemic vessels
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homeostasis/metabolism
hematopoietic system
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• defect in the formation and stabilization of platelet-rich occlusive thrombi after injury
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F11tm1Gjb mutation
(1 available);
any
F11 mutation
(53 available)
Proctm1Fjc mutation
(0 available);
any
Proc mutation
(38 available)
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mortality/aging
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• animals surviving neonatal period either died or were euthanized between 13 and 94 days of age
• oldest survivor euthanized at 94 days of age with severe inflammation, edema, and gangrene in extremities
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• only 8 double homozygotes survived neonatal lethality due to coagulopathy typical of Proctm1Fjc homozygosity
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behavior/neurological
growth/size/body
respiratory system
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• consolidation
• hemorrhage
• fibroblast infiltration of alveolar space
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• degeneration of peritracheal muscle and fat
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• acute and chronic inflammation
• perivascular lymph vessels are distended
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cardiovascular system
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• arterial neointimal formation
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• myocardial degeneration
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• multifocal vacuolization and necrosis
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• ventricular infarction
• atrial clotting
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• significant amounts of lymphatic fluid sometimes accumulate in the thorax
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• in various internal organs and leg muscles
• in bladder at E17.5
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• in the brain and skull plate
• hemorrhage beneath the skull plate seen at E17.5
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• hemorrhagic cysts often seen at the edges of the liver
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• enlarged lymph nodes with areas of hemorrhage
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immune system
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• significant amounts of lymphatic fluid sometimes accumulate in the thorax
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• enlarged lymph nodes with areas of hemorrhage
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• areas of atrophy and edema
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• with areas of hemorrhage
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• acute and chronic inflammation
• perivascular lymph vessels are distended
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hematopoietic system
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• Howell-Jolly bodies sometimes seen
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homeostasis/metabolism
liver/biliary system
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• hemorrhagic cysts often seen at the edges of the liver
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• areas of hyperplasia, mineralization and hemorrhage
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• seen to varying degrees at E17.5
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• fibrotic tissue often seen on edges of the liver
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nervous system
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• in the brain and skull plate
• hemorrhage beneath the skull plate seen at E17.5
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muscle
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• myocardial degeneration
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• multifocal vacuolization and necrosis
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cellular
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• multifocal vacuolization and necrosis
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• gangrene seen in the extremities (nose, tail and paws) of oldest survivor euthanized at 94 days of age with severe inflammation and edema
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• seen to varying degrees at E17.5
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Analysis Tools