Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7tm1Hmas mutation
(0 available);
any
Cdc7 mutation
(34 available)
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mortality/aging
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• mutant embryos die between E3.5-E6.5
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embryo
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• blastocysts grown in culture exhibit a smaller inner cell mass at E6 that continues to diminish in size such that by E8.5 it has disappeared
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7tm1Hmas mutation
(0 available);
any
Cdc7 mutation
(34 available)
Trp53tm2Mok mutation
(2 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• mutant embryos die around E8.5
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embryo
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7tm1Hmas mutation
(0 available);
any
Cdc7 mutation
(34 available)
Tg(EF1A-Cdc7)DKO28Hmas mutation
(0 available)
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mortality/aging
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• about 75% of mice born die within 3 days
• less than 25% survived to adulthood
• survivors have a normal life span
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cellular
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• mouse embryo fibroblast growth slowed considerably
• fewer cells in S phase
• larger numbers of cells in G0 or G1
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• reduced rate of DNA replication
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endocrine/exocrine glands
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• lack oocytes and follicles
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• ovaries are small and grossly malformed
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• reduced number of seminiferous tubules
• reduced spermatogonia
• degenerating primary spermatocytes
• high levels of apoptosis
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growth/size/body
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• mice that survive to adulthood are 50-55% normal size
• major organs are proportional
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immune system
N |
• thymic and periferral lymphocytes normal
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limbs/digits/tail
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• tail flexion anomalies similar to curly-tail (ct) mice
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reproductive system
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• lack oocytes and follicles
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• ovaries are small and grossly malformed
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• total absence of post meiotic cells
• failure in prophase I probably in zygotene stage
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• reduced number of seminiferous tubules
• reduced spermatogonia
• degenerating primary spermatocytes
• high levels of apoptosis
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7tm1Hmas mutation
(0 available);
any
Cdc7 mutation
(34 available)
Tg(EF1A-Cdc7)DKO28Hmas mutation
(0 available)
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normal phenotype
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• mouse embryo fibroblast proliferation and DNA synthesis essentially normal
• body weights normal
• males were fertile
• spermatogenesis restored
• testes remain small
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