Phenotypes associated with this allele

• Allele Symbol: Foxb1^tm1Blh
• Allele Name: targeted mutation 1, Brigid L Hogan
• Allele ID: MGI:2183919
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxb1^tm1Blh/Foxb1^tm1Blh	involves: 129S6/SvEvTac * Black Swiss	MGI:2384396

Genotype
MGI:2384396

hm1

• Allelic Composition: Foxb1^tm1Blh/Foxb1^tm1Blh
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:40034 )

• approximately 1/3 of animals die before weaning; remainder survive up at least to one year of age

lethality throughout fetal growth and development, incomplete penetrance ( J:40034 )

• incomplete penetrance; approximately 8% of homozygotes die at E13.5-E14.5

postnatal lethality, incomplete penetrance ( J:40034 )

• incomplete penetrance; approximately 1/3 of animals die before weaning; remainder survive up at least to one year of age

behavior/neurological

galactostasis ( J:40034 )

♀ • milk is not ejected through nipple; as a result, mutant mammary gland contains more alveoli that are full of milk relative to control gland

♀ • defect corrected by oxytocin injection to mothers

♀ • mammary gland differentiation during pregnancy is normal

limb grasping ( J:40034 )

• hindlimbs are clenched together when suspended by tail; normal mice splay limbs

embryo

caudal body truncation ( J:40034 )

• posterior truncations; incomplete penetrance; in small percentage of embryos

decreased embryo size ( J:40034 )

• incomplete penetrance

open neural tube ( J:40034 )

• incomplete penetrance in embryos; variable in posterior 2/3 of embryos also exhibiting posterior truncations; also between posterior forebrain and midbrain/hindbrain junction

endocrine/exocrine glands

galactostasis ( J:40034 )

♀ • milk is not ejected through nipple; as a result, mutant mammary gland contains more alveoli that are full of milk relative to control gland

♀ • defect corrected by oxytocin injection to mothers

♀ • mammary gland differentiation during pregnancy is normal

growth/size/body

decreased embryo size ( J:40034 )

• incomplete penetrance

decreased body size ( J:40034 )

• mice are about 50% smaller than controls at time of weaning

• after weaning, mice have similar weight gains as controls

nervous system

open neural tube ( J:40034 )

• incomplete penetrance in embryos; variable in posterior 2/3 of embryos also exhibiting posterior truncations; also between posterior forebrain and midbrain/hindbrain junction

integument

galactostasis ( J:40034 )

♀ • milk is not ejected through nipple; as a result, mutant mammary gland contains more alveoli that are full of milk relative to control gland

♀ • defect corrected by oxytocin injection to mothers

♀ • mammary gland differentiation during pregnancy is normal