nervous system

abnormal Schwann cell morphology ( J:98118 )

• Schwann cell density is increased from P21 onwards compared to in wild-type mice

• however, Schwann cell proliferation is normal at P21

• beginning at P4, Schwann cell apoptosis rates are double wild-type rates

abnormal myelination ( J:98118 )

• mice exhibit almost complete amyelination

Mouse Models of Human Disease		OMIM ID	Ref(s)
Charcot-Marie-Tooth Disease, Demyelinating, Type 1A; CMT1A		118220	J:98118