Mouse Genome Informatics
tg1
    Tg(Pmp22)247Ueli/0
involves: C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• Schwann cell density is increased from P21 onwards compared to in wild-type mice
• Schwann cell density is increased from P21 onwards compared to in wild-type mice
• however, Schwann cell proliferation is normal at P21
• beginning at P4, Schwann cell apoptosis rates are double wild-type rates
• mice exhibit almost complete amyelination

Mouse Models of Human Disease
OMIM IDRef(s)
Charcot-Marie-Tooth Disease, Demyelinating, Type 1A; CMT1A 118220 J:98118