Phenotypes associated with this allele

• Allele Symbol: Agt^tm1Ii
• Allele Name: targeted mutation 1, Iekuni Ichikawa
• Allele ID: MGI:2183545
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agt^tm1Ii/Agt^tm1Ii	involves: 129P2/OlaHsd * C57BL/6	MGI:3639272
ht2	Agt^tm1Ii/Agt^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3639275

Genotype
MGI:3639272

hm1

• Allelic Composition: Agt^tm1Ii/Agt^tm1Ii
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal kidney morphology in 3 week old Agt^tm1Ii/Agt^tm1Ii mice

renal/urinary system

abnormal kidney morphology ( J:140022 )

dilated kidney collecting duct ( J:30061 )

• by 3 weeks, dilated collecting ducts are more evident in the outer medulla

abnormal kidney cortex morphology ( J:30061 )

• although hypotensive at 7 weeks of age, 3-wk-old homozygotes display prominent lesions in the renal cortex, similar to those observed in hypertensive nephrosclerosis

abnormal kidney afferent arteriole morphology ( J:30061 )

• by 3 weeks, medial hyperplasia is evident in afferent arterioles

abnormal kidney cortex artery morphology ( J:30061 )

• at 1 week of age, homozygotes display mild thickening of arterial walls in cortical vessels

• by 3 weeks, medial hyperplasia is evident in interlobular arteries and afferent arterioles whereas the main branches of the renal artery appear normal

abnormal kidney interlobular artery morphology ( J:30061 )

• by 3 weeks, medial hyperplasia is evident in interlobular arteries

abnormal renal glomerulus morphology ( J:30061 , J:140022 )

• at birth and at 1 week of age, homozygotes show a modest delay in glomerular maturation, primarily in the inner zone of the cortex (J:30061)

• glomerular maturation is more pronounced at 1 week, as shown by large numbers of glomeruli with cuboidal epithelial cells and simple capillary configuration (J:30061)

• by 3 weeks, homozygotes exhibit a significantly reduced glomerular tuft area relative to wild-type mice (J:30061)

• size is increased on a high salt diet and decreased on a low salt diet (J:140022)

expanded mesangial matrix ( J:30061 )

• at 3 weeks, homozygotes show axial mesangial expansion around the stalk near the vascular pole

renal interstitial fibrosis ( J:30061 )

• at 3 weeks, homozygotes show mild but distinct interstitial fibrosis with mononuclear cell infiltrates

kidney papillary atrophy ( J:30061 )

kidney papillary hypoplasia ( J:30061 )

• at 3 weeks, homozygotes exhibit atrophic or hypoplastic kidney papillae

hydronephrosis ( J:30061 )

• at 3 weeks, homozygotes display pelvic dilatation due to atrophic papillae

dilated renal tubule ( J:30061 )

• at 1 week of age, homozygotes show mild tubular dilation without intestitial fibrosis in the outer medulla

abnormal renal/urinary system physiology ( J:140022 )

decreased urine osmolality ( J:140022 )

abnormal renal filtration rate ( J:140022 )

• decreased inulin clearance on high normal or low sodium diets

increased urine flow rate ( J:140022 )

• increased urine flow rate

cardiovascular system

abnormal kidney afferent arteriole morphology ( J:30061 )

• by 3 weeks, medial hyperplasia is evident in afferent arterioles

abnormal kidney cortex artery morphology ( J:30061 )

• at 1 week of age, homozygotes display mild thickening of arterial walls in cortical vessels

• by 3 weeks, medial hyperplasia is evident in interlobular arteries and afferent arterioles whereas the main branches of the renal artery appear normal

abnormal kidney interlobular artery morphology ( J:30061 )

• by 3 weeks, medial hyperplasia is evident in interlobular arteries

decreased heart weight ( J:30061 )

• at 3 weeks, homozygotes display a reduction in average heart weight; however, this difference does not reach statistical significance

decreased systemic arterial blood pressure ( J:46007 )

• in conscious animals, blood pressure averages 72 mm Hg vs 106 mm Hg in wild

• under anesthesia, baseline MAP is 45 mm Hg vs 96 mm Hg in wild-type

decreased systemic arterial systolic blood pressure ( J:30061 )

• at 7-8 weeks of age, homozygotes exhibit significantly reduced systolic blood pressure relative to wild-type mice (average SBP: 77 mmHg vs 118 mmHg, respectively)

growth/size/body

abnormal postnatal growth/weight/body size ( J:30061 )

• at 1 week of age, homozygotes display a delayed weigh gain which is more apparent at 3 weeks

liver/biliary system

decreased liver weight ( J:30061 )

• at 3 weeks, homozygotes exhibit a reduced liver weight relative to wild-type mice

homeostasis/metabolism

increased circulating creatinine level ( J:140022 )

• two fold higher than controls on high, normal, or low salt diets

decreased urine osmolality ( J:140022 )

behavior/neurological

increased fluid intake ( J:140022 )

• higher water intake relative to controls

Genotype
MGI:3639275

ht2

• Allelic Composition: Agt^tm1Ii/Agt⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:30061 )

• at 7-8 weeks of age, heterozygotes exhibit reduced systolic blood pressure relative to wild-type mice (average SBP: 97 mmHg vs 118 mmHg, respectively)