Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf14tm1Dor mutation
(0 available);
any
Fgf14 mutation
(40 available)
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growth/size/body
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• Background Sensitivity: growth lags behind controls during the 3rd and 4th weeks of life but parallels growth in controls at all other times
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behavior/neurological
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• nonepileptic forelimb clonic spasms and hyperextension of hindlimbs - paroxysmal dyskinesia
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• retract hind feet and clench digits when suspended by the tail
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• poor performance on both a ledge and a platform test
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• poor performance on an accelerating rotarod test and no improvement with practice
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• inferior ability to climb on an inclined screen
• inability to stay on in an inverted screen test
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• slow to initiate movement although overall activity levels are normal
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• shuffling footprint pattern
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nervous system
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• hyperactive response to cocaine, amphetamine, and specific dopamine receptor agonists is reduced
• impaired dopamine 2 receptor-mediated signalling
• both the striatonigral and striatopallial nerve pathways function abnormally although the striatopallial pathway is affected more
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf14tm1Dor mutation
(0 available);
any
Fgf14 mutation
(40 available)
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growth/size/body
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• Background Sensitivity: growth of mice on a B6 background is normal through weaning although adult weight is 15% smaller than controls
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behavior/neurological
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• mice exhibit impaired acquisition performance during place trials in both escape path length and latency to find the submerged platform
• mice also show impaired acquisition performance when they are restested in the water maze and required to learn another submerged platform location in the presence of different spatial cues
• increasing the memory load for the water navigation task results in performance deficits in mice that are not seen with less challenging memory demands
• however, mice exhibit normal conditioned fear and passive avoidance performance
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• nonepileptic forelimb clonic spasms and hyperextension of hindlimbs - paroxysmal dyskinesia
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• retract hind feet and clench digits when suspended by the tail
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(J:134733)
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• poor performance on both a ledge and a platform test
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• poor performance on an accelerating rotarod test and no improvement with practice
(J:77806)
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• mice exhibit impaired performance on the platform and inverted screen and on the constant speed and accelerating rotarod
(J:134733)
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• inferior ability to climb on an inclined screen
(J:77806)
• inability to stay on in an inverted screen test
(J:77806)
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• mice show reduced forelimb strength in gripping a bar
(J:134733)
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• slow to initiate movement although overall activity levels are normal
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• shuffling footprint pattern
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• mice are hyperactive, showing more ambulations than wild-type mice during a 1 hour test period
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nervous system
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• hyperactive response to cocaine, amphetamine, and specific dopamine receptor agonists is reduced
• impaired dopamine 2 receptor-mediated signalling
• both the striatonigral and striatopallial nerve pathways function abnormally although the striatopallial pathway is affected more
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• mice exhibit impaired theta burst induced LTP
• however, mice show normal hippocampus, parahippocampal region and amygdala anatomy
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf14tm1Dor mutation
(0 available);
any
Fgf14 mutation
(40 available)
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behavior/neurological
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• mice exhibit grip weakness when tested on an inverted grid and show shortened ledge retention time compared to wild-type mice
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nervous system
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• most Purkinje neurons lack spontaneous and tonic firing
• however, individual action potential waveforms in Purkinje cells and evoked excitatory postsynaptic currents (EPSCs) in Purkinje neurons are similar to wild-type mice
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• granule neuron excitability is impaired
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf12tm1Gol mutation
(0 available);
any
Fgf12 mutation
(16 available)
Fgf14tm1Dor mutation
(0 available);
any
Fgf14 mutation
(40 available)
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behavior/neurological
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• mice exhibit increased activity when placed in a new environment
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• mice fall off a grid when titled at a 45 degree angle and do not pull a rod with any measurable force when pulled backwards by their tails
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• mice exhibit increased activity when disturbed or placed in a new environment
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nervous system
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• granule neuron excitability is more severely impaired than in Fgf14tm1Dor mice (1 firing compared to 2 in Fgf14tm1Dor mice)
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• sodium channel inactivation parameters are altered in cerebellar granule neurons
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Analysis Tools