Phenotypes associated with this allele

• Allele Symbol: Ezh2^tm1Jnw
• Allele Name: targeted mutation 1, Thomas Jenuwein
• Allele ID: MGI:2182844
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ezh2^tm1Jnw/Ezh2^tm1Jnw	involves: 129P2/OlaHsd	MGI:3035988

Genotype
MGI:3035988

hm1

• Allelic Composition: Ezh2^tm1Jnw/Ezh2^tm1Jnw
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:69977 )

• homozygous embryos die between E7.5 and E10.5

embryo

absent inner cell mass proliferation ( J:69977 )

• some embryos exhibit a failure of the ICM to grow in culture

failure to gastrulate ( J:69977 )

• some embryos initiate but do not complete gastrulation

embryonic growth retardation ( J:69977 )

• homozygous embryos are described as growth retarded

abnormal embryonic tissue morphology ( J:69977 )

• a reduced amount of embryonic tissue was present

abnormal extraembryonic tissue morphology ( J:69977 )

• increased amounts of extraembryonic tissue were present

growth/size/body

embryonic growth retardation ( J:69977 )

• homozygous embryos are described as growth retarded

cellular

absent inner cell mass proliferation ( J:69977 )

• some embryos exhibit a failure of the ICM to grow in culture