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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zfpm2tm1Jml
targeted mutation 1, Jeffrey M Leiden
MGI:2182616
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zfpm2tm1Jml/Zfpm2tm1Jml involves: 129X1/SvJ MGI:3620558
cx2
Atoh8tm1.1Mlkn/Atoh8tm1.1Mlkn
Zfpm2tm1Jml/Zfpm2+
involves: 129 * 129X1/SvJ * C57BL/6 MGI:5532941


Genotype
MGI:3620558
hm1
Allelic
Composition
Zfpm2tm1Jml/Zfpm2tm1Jml
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfpm2tm1Jml mutation (0 available); any Zfpm2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• large atrioventricular canal-type atrial septal defect
• display a single, poorly formed, L-sided common atrioventricular valve that connects both atria to the left ventricle
• the compact zone of the left ventricle myocardium is thinner
• smaller size of the right ventricle cavity
• pulmonic outflow tract is longer, hyperplastic, and narrowed
• position of the aortic outflow tract is abnormal, with a longer length and unusual shape behind the right ventricle
• rightward displacement of the aortic valve
• pulmonary valve is longer, hyperplastic, and thickened
• thickened pulmonic valve
• narrowing of the pulmonic outflow tract

homeostasis/metabolism
• subcutaneous edema

integument
• subcutaneous edema

Mouse Models of Human Disease
OMIM ID Ref(s)
Tricuspid Atresia 605067 J:63121




Genotype
MGI:5532941
cx2
Allelic
Composition
Atoh8tm1.1Mlkn/Atoh8tm1.1Mlkn
Zfpm2tm1Jml/Zfpm2+
Genetic
Background
involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh8tm1.1Mlkn mutation (0 available); any Atoh8 mutation (2 available)
Zfpm2tm1Jml mutation (0 available); any Zfpm2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable and present at the expected Mendelian ratio at P1 and P14





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory