All Phenotypes Dlg4<tm1Grnt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dlg4^tm1Grnt
targeted mutation 1, Seth G N Grant
MGI:2182460

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlg4^tm1Grnt/Dlg4^tm1Grnt	involves: 129P2/OlaHsd * C57BL/6JIco	MGI:5641694
hm2	Dlg4^tm1Grnt/Dlg4^tm1Grnt	involves: 129P2/OlaHsd * MF1	MGI:2651586
cx3	Dlg3^tm1Grnt/Dlg3^tm1Grnt Dlg4^tm1Grnt/Dlg4^tm1Grnt	involves: 129P2/OlaHsd * MF1	MGI:3707226
cx4	Dlg3^tm1Grnt/Dlg3⁺ Dlg4^tm1Grnt/Dlg4^tm1Grnt	involves: 129P2/OlaHsd * MF1	MGI:3707225
cx5	Dlg4^tm1Grnt/Dlg4^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺	involves: 129P2/OlaHsd * MF1	MGI:3581308
cx6	Dlg3^tm1Grnt/Y Dlg4^tm1Grnt/Dlg4^tm1Grnt	involves: 129P2/OlaHsd * MF1	MGI:3707224

Allelic Composition	Dlg4^tm1Grnt/Dlg4^tm1Grnt
Genetic Background	involves: 129P2/OlaHsd * C57BL/6JIco

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg4^tm1Grnt mutation (0 available); any Dlg4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal sebaceous gland morphology ( J:209956 )

• mice show sebaceous glands with irregular surfaces

integument

abnormal sebaceous gland morphology ( J:209956 )

• mice show sebaceous glands with irregular surfaces

Allelic Composition	Dlg4^tm1Grnt/Dlg4^tm1Grnt
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg4^tm1Grnt mutation (0 available); any Dlg4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:77693 )

• reduced numbers of homozygotes relative to expected when tested after birth

growth/size/body

decreased body size ( J:77693 )

• 42% are initially runted but attain normal size by 6 weeks of age

nervous system

abnormal forebrain morphology ( J:109664 )

abnormal striatum morphology ( J:109664 )

• density of dendritic spines significantly reduced (by about 20%)

abnormal hippocampus pyramidal cell morphology ( J:109664 )

• density of dendritic spines of the apical dendrites of CA1 pyramidal neurons is about 40% higher between 60 and 80 micrometers from the cell body

• neuron morphology is otherwise normal

abnormal CNS synaptic transmission ( J:77693 )

enhanced long-term potentiation ( J:77693 , J:98903 )

• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation than in wildtype (J:98903)

enhanced paired-pulse facilitation ( J:77693 )

• at interpulse intervals of 20, 50,100, and 200 ms in CA1 pyramidal cells

behavior/neurological

abnormal spatial learning ( J:77693 , J:98903 )

• slower learning in a series of water maze tests (J:77693)

• homozygotes learn little in the spatial water maze test regardless of the amount of training received (J:98903)

abnormal pain threshold ( J:82335 )

• fail to develop thermal hyperalgesia and mechanical allodynia after chronic constriction injury of the sciatic nerve

allodynia ( J:82335 )

• cold allodynia severely attenuated relative to controls after chronic constriction injury of the sciatic nerve

Allelic Composition	Dlg3^tm1Grnt/Dlg3^tm1Grnt Dlg4^tm1Grnt/Dlg4^tm1Grnt
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg3^tm1Grnt mutation (0 available); any Dlg3 mutation (28 available)
Dlg4^tm1Grnt mutation (0 available); any Dlg4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:120078 )

• crosses of heterozygous Dlg3 and Dlg4 mice produce no double homozygotes; double mutants die perinatally with none surviving past day 3 postnatal

Allelic Composition	Dlg3^tm1Grnt/Dlg3⁺ Dlg4^tm1Grnt/Dlg4^tm1Grnt
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:120078 )

• crosses of heterozygous Dlg3 and Dlg4 mice produce a very low proportion of Dlg3^tm1Grnt/+, Dlg4-null female mice

Allelic Composition	Dlg4^tm1Grnt/Dlg4^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg4^tm1Grnt mutation (0 available); any Dlg4 mutation (42 available)
Syngap1^tm1Grnt mutation (0 available); any Syngap1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

enhanced long-term potentiation ( J:98903 )

• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation (LTP) than in wildtype, which was similar to the LTP seen in single homozygous Dlgh4 mice

Allelic Composition	Dlg3^tm1Grnt/Y Dlg4^tm1Grnt/Dlg4^tm1Grnt
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:120078 )

• no Dlg3^tm1Grnt/y, Dlg4-null male mice mice are produced by crosses of heterozygous Dlg3 and Dlg4 mice; double mutants die perinatally

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