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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dlg4tm1Grnt
targeted mutation 1, Seth G N Grant
MGI:2182460
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dlg4tm1Grnt/Dlg4tm1Grnt involves: 129P2/OlaHsd * C57BL/6JIco MGI:5641694
hm2
Dlg4tm1Grnt/Dlg4tm1Grnt involves: 129P2/OlaHsd * MF1 MGI:2651586
cx3
Dlg3tm1Grnt/Dlg3tm1Grnt
Dlg4tm1Grnt/Dlg4tm1Grnt
involves: 129P2/OlaHsd * MF1 MGI:3707226
cx4
Dlg3tm1Grnt/Dlg3+
Dlg4tm1Grnt/Dlg4tm1Grnt
involves: 129P2/OlaHsd * MF1 MGI:3707225
cx5
Dlg4tm1Grnt/Dlg4tm1Grnt
Syngap1tm1Grnt/Syngap1+
involves: 129P2/OlaHsd * MF1 MGI:3581308
cx6
Dlg3tm1Grnt/Y
Dlg4tm1Grnt/Dlg4tm1Grnt
involves: 129P2/OlaHsd * MF1 MGI:3707224


Genotype
MGI:5641694
hm1
Allelic
Composition
Dlg4tm1Grnt/Dlg4tm1Grnt
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6JIco
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg4tm1Grnt mutation (0 available); any Dlg4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice show sebaceous glands with irregular surfaces

integument
• mice show sebaceous glands with irregular surfaces




Genotype
MGI:2651586
hm2
Allelic
Composition
Dlg4tm1Grnt/Dlg4tm1Grnt
Genetic
Background
involves: 129P2/OlaHsd * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg4tm1Grnt mutation (0 available); any Dlg4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced numbers of homozygotes relative to expected when tested after birth

growth/size/body
• 42% are initially runted but attain normal size by 6 weeks of age

nervous system
• density of dendritic spines significantly reduced (by about 20%)
• density of dendritic spines of the apical dendrites of CA1 pyramidal neurons is about 40% higher between 60 and 80 micrometers from the cell body
• neuron morphology is otherwise normal
• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation than in wildtype (J:98903)
• at interpulse intervals of 20, 50,100, and 200 ms in CA1 pyramidal cells

behavior/neurological
• slower learning in a series of water maze tests (J:77693)
• homozygotes learn little in the spatial water maze test regardless of the amount of training received (J:98903)
• fail to develop thermal hyperalgesia and mechanical allodynia after chronic constriction injury of the sciatic nerve
• cold allodynia severely attenuated relative to controls after chronic constriction injury of the sciatic nerve

integument
• fail to develop thermal hyperalgesia and mechanical allodynia after chronic constriction injury of the sciatic nerve
• cold allodynia severely attenuated relative to controls after chronic constriction injury of the sciatic nerve




Genotype
MGI:3707226
cx3
Allelic
Composition
Dlg3tm1Grnt/Dlg3tm1Grnt
Dlg4tm1Grnt/Dlg4tm1Grnt
Genetic
Background
involves: 129P2/OlaHsd * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg3tm1Grnt mutation (0 available); any Dlg3 mutation (25 available)
Dlg4tm1Grnt mutation (0 available); any Dlg4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• crosses of heterozygous Dlg3 and Dlg4 mice produce no double homozygotes; double mutants die perinatally with none surviving past day 3 postnatal




Genotype
MGI:3707225
cx4
Allelic
Composition
Dlg3tm1Grnt/Dlg3+
Dlg4tm1Grnt/Dlg4tm1Grnt
Genetic
Background
involves: 129P2/OlaHsd * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg3tm1Grnt mutation (0 available); any Dlg3 mutation (25 available)
Dlg4tm1Grnt mutation (0 available); any Dlg4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• crosses of heterozygous Dlg3 and Dlg4 mice produce a very low proportion of Dlg3tm1Grnt/+, Dlg4-null female mice




Genotype
MGI:3581308
cx5
Allelic
Composition
Dlg4tm1Grnt/Dlg4tm1Grnt
Syngap1tm1Grnt/Syngap1+
Genetic
Background
involves: 129P2/OlaHsd * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg4tm1Grnt mutation (0 available); any Dlg4 mutation (25 available)
Syngap1tm1Grnt mutation (0 available); any Syngap1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation (LTP) than in wildtype, which was similar to the LTP seen in single homozygous Dlgh4 mice




Genotype
MGI:3707224
cx6
Allelic
Composition
Dlg3tm1Grnt/Y
Dlg4tm1Grnt/Dlg4tm1Grnt
Genetic
Background
involves: 129P2/OlaHsd * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg3tm1Grnt mutation (0 available); any Dlg3 mutation (25 available)
Dlg4tm1Grnt mutation (0 available); any Dlg4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no Dlg3tm1Grnt/y, Dlg4-null male mice mice are produced by crosses of heterozygous Dlg3 and Dlg4 mice; double mutants die perinatally





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory