All Phenotypes Tacr1<tm1Sph> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tacr1^tm1Sph
targeted mutation 1, Stephen P Hunt
MGI:2182395

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129 * C57BL/6	MGI:3621187
hm2	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129P2/OlaHsd	MGI:4821001
hm3	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129P2/OlaHsd * C57BL/6	MGI:3619726
hm4	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129P2/OlaHsd * C57BL/6 * MF1	MGI:3619727

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:106301 )

• superfusion of the medulla and spinal cord of P1 nulls with aCSF containing SP did not change the respiratory frequency or amplitude of motor outpur significantly, whereas in wild-type preparations, the respiratory frequency increased to 147.9% of conrol

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:171881 )

• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired behavioral response to morphine ( J:171881 )

• morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired conditioned place preference behavior ( J:171881 )

• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired coordination ( J:171881 )

• on a rotarod

hyperactivity ( J:171881 )

• mice exhibit hyperactivity compared with wild-type mice

• however, hyperactivity is rescued by D-amphetamine or methylphenidate treatment

abnormal pain threshold ( J:127006 )

• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice

homeostasis/metabolism

abnormal dopamine level ( J:171881 )

• mice exhibit reduced basal dopamine efflux in the frontal cortex compared with wild-type mice

• amphetamine-treated mice lack a dopamine response compared with wild-type mice

abnormal noradrenaline level ( J:171881 )

• after a second potassium ion challenge, extracellular noradrenaline level is increased unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:171881

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased aggression ( J:46629 )

abnormal touch/ nociception ( J:46629 )

abnormal chemical nociception ( J:46629 )

• response to noxious stimuli not corollated to intensity of stimuli

• behavioral response to nociceptive thresholds unaffected

abnormal pain threshold ( J:46629 )

• stress induced analgesia reduced

hyperalgesia ( J:103700 )

• less increase in sensitivity to pain after M. tuberculosis infection than in controls

nervous system

decreased nerve fiber response intensity ( J:46629 )

• repetitive stimulation of unmyelinated fibers failed to increase response to subsequent stimulations

immune system

decreased inflammatory response ( J:46629 )

• inflammatory response to some noxious substances reduced

joint inflammation ( J:103700 )

• reduced synovial hyperplasia and inflammatory infiltrates

skeleton

joint inflammation ( J:103700 )

• reduced synovial hyperplasia and inflammatory infiltrates

respiratory system

abnormal respiratory mucosa goblet cell morphology ( J:105592 )

• less goblet cell hyperplasia in lungs after exposure to ovalbumin

abnormal pulmonary respiratory rate response ( J:89428 )

• respiratory frequency fails to increase in adult mice in response to hypoxia

increased airway responsiveness ( J:105592 )

• increased bronchoconstriction in response to carbachol

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:102131 )

• increased locomotor activity in light/dark box tests

abnormal thermosensation ( J:106631 )

• fail to develop morphine induced hypersensitivity to heat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23