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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tacr1tm1Sph
targeted mutation 1, Stephen P Hunt
MGI:2182395
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tacr1tm1Sph/Tacr1tm1Sph involves: 129 * C57BL/6 MGI:3621187
hm2
Tacr1tm1Sph/Tacr1tm1Sph involves: 129P2/OlaHsd MGI:4821001
hm3
Tacr1tm1Sph/Tacr1tm1Sph involves: 129P2/OlaHsd * C57BL/6 MGI:3619726
hm4
Tacr1tm1Sph/Tacr1tm1Sph involves: 129P2/OlaHsd * C57BL/6 * MF1 MGI:3619727


Genotype
MGI:3621187
hm1
Allelic
Composition
Tacr1tm1Sph/Tacr1tm1Sph
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1tm1Sph mutation (3 available); any Tacr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• superfusion of the medulla and spinal cord of P1 nulls with aCSF containing SP did not change the respiratory frequency or amplitude of motor outpur significantly, whereas in wild-type preparations, the respiratory frequency increased to 147.9% of conrol




Genotype
MGI:4821001
hm2
Allelic
Composition
Tacr1tm1Sph/Tacr1tm1Sph
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1tm1Sph mutation (3 available); any Tacr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice
• morphine-treated mice lack conditioned place preference unlike wild-type mice
• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice
• on a rotarod
• mice exhibit hyperactivity compared with wild-type mice
• however, hyperactivity is rescued by D-amphetamine or methylphenidate treatment
• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice

nervous system
• after a second potassium ion challenge, extracellular noradrenaline level is increased unlike in wild-type mice

homeostasis/metabolism
• mice exhibit reduced basal dopamine efflux in the frontal cortex compared with wild-type mice
• amphetamine-treated mice lack a dopamine response compared with wild-type mice
• after a second potassium ion challenge, extracellular noradrenaline level is increased unlike in wild-type mice

integument
• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice




Genotype
MGI:3619726
hm3
Allelic
Composition
Tacr1tm1Sph/Tacr1tm1Sph
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1tm1Sph mutation (3 available); any Tacr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• response to noxious stimuli not corollated to intensity of stimuli
• behavioral response to nociceptive thresholds unaffected
• stress induced analgesia reduced
• less increase in sensitivity to pain after M. tuberculosis infection than in controls

nervous system
• repetitive stimulation of unmyelinated fibers failed to increase response to subsequent stimulations

immune system
• inflammatory response to some noxious substances reduced
• reduced synovial hyperplasia and inflammatory infiltrates

skeleton
• reduced synovial hyperplasia and inflammatory infiltrates

respiratory system
• less goblet cell hyperplasia in lungs after exposure to ovalbumin
• respiratory frequency fails to increase in adult mice in response to hypoxia
• increased bronchoconstriction in response to carbachol

integument
• response to noxious stimuli not corollated to intensity of stimuli
• behavioral response to nociceptive thresholds unaffected
• stress induced analgesia reduced
• less increase in sensitivity to pain after M. tuberculosis infection than in controls




Genotype
MGI:3619727
hm4
Allelic
Composition
Tacr1tm1Sph/Tacr1tm1Sph
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1tm1Sph mutation (3 available); any Tacr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increased locomotor activity in light/dark box tests
• fail to develop morphine induced hypersensitivity to heat





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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory