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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nkx6-2tm1Qiu
targeted mutation 1, Mengsheng Qiu
MGI:2182286
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nkx6-2tm1Qiu/Nkx6-2tm1Qiu Not Specified MGI:3608657
cn2
Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+
Nkx6-2tm1Qiu/Nkx6-2tm1(cre/ERT2)Fsh
involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster MGI:4412378


Genotype
MGI:3608657
hm1
Allelic
Composition
Nkx6-2tm1Qiu/Nkx6-2tm1Qiu
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-2tm1Qiu mutation (0 available); any Nkx6-2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes are viable and fertile with normal testis histology and no apparent abnormalities in the specification and differentiation of oligodendrocytes and neuronal cells in the CNS




Genotype
MGI:4412378
cn2
Allelic
Composition
Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+
Nkx6-2tm1Qiu/Nkx6-2tm1(cre/ERT2)Fsh
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Nkx6-2tm1(cre/ERT2)Fsh mutation (1 available); any Nkx6-2 mutation (11 available)
Nkx6-2tm1Qiu mutation (0 available); any Nkx6-2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following tamoxifen treatment at E12.5, mice exhibit a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons compared with wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory