All Phenotypes Nkx6-2<tm1Qiu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx6-2^tm1Qiu
targeted mutation 1, Mengsheng Qiu
MGI:2182286

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx6-2^tm1Qiu/Nkx6-2^tm1Qiu	Not Specified	MGI:3608657
cn2	Gt(ROSA)26Sor^{tm1.1(CAG-EGFP)Fsh}/Gt(ROSA)26Sor⁺ Nkx6-2^tm1Qiu/Nkx6-2^{tm1(cre/ERT2)Fsh}	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster	MGI:4412378

Allelic Composition	Nkx6-2^tm1Qiu/Nkx6-2^tm1Qiu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-2^tm1Qiu mutation (0 available); any Nkx6-2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:69975 )

• homozygotes are viable and fertile with normal testis histology and no apparent abnormalities in the specification and differentiation of oligodendrocytes and neuronal cells in the CNS

Allelic Composition	Gt(ROSA)26Sor^{tm1.1(CAG-EGFP)Fsh}/Gt(ROSA)26Sor⁺ Nkx6-2^tm1Qiu/Nkx6-2^{tm1(cre/ERT2)Fsh}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1.1(CAG-EGFP)Fsh} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Nkx6-2^{tm1(cre/ERT2)Fsh} mutation (1 available); any Nkx6-2 mutation (16 available)
Nkx6-2^tm1Qiu mutation (0 available); any Nkx6-2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain interneuron morphology ( J:155164 )

• following tamoxifen treatment at E12.5, mice exhibit a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23