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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*G37R)106Dpr
transgene insertion 106, Donald L Price
MGI:2182087
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(SOD1*G37R)106Dpr/0 involves: C3H/HeJ * C57BL/6J MGI:3814056


Genotype
MGI:3814056
tg1
Allelic
Composition
Tg(SOD1*G37R)106Dpr/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at late stages
• motor neuron degeneration is observed in the ventral horns of the lumbar, thoracic, and cervical spinal cord as well as the brain stem
• degeneration is associated with vacuole formation in both dendrites and axons of motor neurons

behavior/neurological
• at 5.5 to 7.5 months of age, mice exhibit axial tremors
• at 5.5 to 7.5 months of age, mice exhibit asymmetric weakness of the limbs and when suspended by their tail exhibit difficulties extending and moving hindlimbs
• at 5.5 to 7.5 months of age, mice exhibit decreased spontaneous movement compared to wild-type mice
• eventually mice develop hindlimb paralysis

muscle
• at 5.5 to 7.5 months of age, mice exhibit muscle wasting particularly along the flanks
• mice exhibit spontaneous, positive sharp waves associated with denervation atrophy

cellular
• motor neurons exhibit mitochondrial degradation

growth/size/body
• progressive

integument
• at 5.5 to 7.5 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:69178





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory