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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja4tm1Paul
targeted mutation 1, David L Paul
MGI:2181813
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gja4tm1Paul/Gja4tm1Paul either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) MGI:2651405
cx2
 		Gja4tm1Paul/Gja4tm1Paul
Gja5tm1Paul/Gja5tm1Paul 		involves: 129S4/SvJae * C57BL/6 MGI:3629933


Genotype
MGI:2651405
hm1
Allelic
Composition		 Gja4tm1Paul/Gja4tm1Paul
Genetic
Background		 either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja4tm1Paul mutation (1 available); any Gja4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal corpus luteum morphology ( J:38247 )
• premature formation of corpora lutea
anovulation ( J:38247 )
• absence of ovulation

endocrine/exocrine glands
abnormal corpus luteum morphology ( J:38247 )
• premature formation of corpora lutea




Genotype
MGI:3629933
cx2
Allelic
Composition		 Gja4tm1Paul/Gja4tm1Paul
Gja5tm1Paul/Gja5tm1Paul
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja4tm1Paul mutation (1 available); any Gja4 mutation (15 available)
Gja5tm1Paul mutation (1 available); any Gja5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:80178 )
• incomplete penetrance; reduced embryonic viability at E14.5
neonatal lethality, incomplete penetrance ( J:80178 )
• animals died within 2 days after birth
postnatal lethality, complete penetrance ( J:80178 )
• animals died within 2 days after birth

reproductive system
abnormal testis morphology ( J:80178 )
• extensive blood filled region of testes; congested, thin walled vascular channels in between testicular cord tissue
abnormal spermatogenesis ( J:80178 )
• mild to severe sperm vacuolar degeneration and necrosis

cardiovascular system
lung hemorrhage ( J:80178 )
• 45% of animals displayed blood-filled lungs
gastrointestinal hemorrhage ( J:80178 )
• enlarged blood vessels in intestinal or gastric wall
increased vasodilation ( J:80178 )
• dilated blood vessels observed in skin near hematomas; subcutaneous hematomas observed on dorsal surface of the animal, especially on the head and also on the neck, shoulders, and posterior regions

digestive/alimentary system
gastrointestinal hemorrhage ( J:80178 )
• enlarged blood vessels in intestinal or gastric wall

respiratory system
lung hemorrhage ( J:80178 )
• 45% of animals displayed blood-filled lungs

endocrine/exocrine glands
abnormal testis morphology ( J:80178 )
• extensive blood filled region of testes; congested, thin walled vascular channels in between testicular cord tissue

muscle
increased vasodilation ( J:80178 )
• dilated blood vessels observed in skin near hematomas; subcutaneous hematomas observed on dorsal surface of the animal, especially on the head and also on the neck, shoulders, and posterior regions




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory