Phenotypes associated with this allele

• Allele Symbol: Kcnab1^tm1Sva
• Allele Name: targeted mutation 1, Alcino J Silva
• Allele ID: MGI:2181771
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnab1^tm1Sva/Kcnab1^tm1Sva	B6.129-Kcnab1^tm1Sva	MGI:3583155
hm2	Kcnab1^tm1Sva/Kcnab1^tm1Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3583152

Genotype
MGI:3583155

hm1

• Allelic Composition: Kcnab1^tm1Sva/Kcnab1^tm1Sva
• Genetic Background: B6.129-Kcnab1^tm1Sva

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal afterhyperpolarization ( J:94633 )

• Background Sensitivity: smaller post-burst after hyperpolarization following repetitive spiking does not occur when C57BL/6J becomes more prominent in the genetic background

behavior/neurological

abnormal spatial learning ( J:94633 )

• Background Sensitivity: aged mice do not persist in searching the training quadrant when C57BL/6J becomes more prominent in the genetic background

Genotype
MGI:3583152

hm2

• Allelic Composition: Kcnab1^tm1Sva/Kcnab1^tm1Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

nervous system

abnormal nervous system electrophysiology ( J:51147 )

abnormal action potential ( J:51147 )

• frequency dependent spike broadening of CA1 action potentials is decreased

• Background Sensitivity: significantly smaller post-burst after hyperpolarization following repetitive spiking

abnormal afterhyperpolarization ( J:94633 )

• Background Sensitivity: significantly smaller post-burst after hyperpolarization following repetitive spiking

enhanced long-term potentiation ( J:94633 )

• under minimal stimulation in aged mice

behavior/neurological

impaired social transmission of food preference ( J:51147 , J:89719 )

• after aging or when raised in an "enriched" environment, impairment corrected (J:89719)

abnormal inhibitory learning ( J:51147 )

• no hippocampal based learning deficit using a water maze however mice are slow to learn a new location after the platform is moved

• after aging or when raised in an enriched environment, learning impairment improved

abnormal spatial learning ( J:51147 , J:89719 , J:94633 )

• aged mice persisted in searching the training quadrant (J:51147)