Phenotypes associated with this allele

• Allele Symbol: Csf2rb^tm1Cgb
• Allele Name: targeted mutation 1, C Glenn Begley
• Allele ID: MGI:2181245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csf2rb^tm1Cgb/Csf2rb^tm1Cgb	involves: 129S1/Sv * C57BL/6	MGI:3723079

Genotype
MGI:3723079

hm1

• Allelic Composition: Csf2rb^tm1Cgb/Csf2rb^tm1Cgb
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal myeloblast morphology/development ( J:29737 )

• in clonal cultures of mutant bone marrow cells, even high concentrations of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5 fail to stimulate colony formation, but cells show normal responsiveness to stimulation by IL-3 and other growth factors

decreased eosinophil cell number ( J:29737 )

• eosinophil numbers in the peripheral blood and bone marrow are reduced by 95%

immune system

decreased eosinophil cell number ( J:29737 )

• eosinophil numbers in the peripheral blood and bone marrow are reduced by 95%

lung inflammation ( J:29737 )

• develop pulmonary peribronchovascular lymphoid infiltrates and intraalveolar eosinophilic material and foamy macrophages are present

respiratory system

pulmonary alveolar proteinosis ( J:29737 )

• mutants exhibit areas resembling alveolar proteinosis

lung inflammation ( J:29737 )

• develop pulmonary peribronchovascular lymphoid infiltrates and intraalveolar eosinophilic material and foamy macrophages are present

homeostasis/metabolism

pulmonary alveolar proteinosis ( J:29737 )

• mutants exhibit areas resembling alveolar proteinosis