Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
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growth/size/body
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• after 7 months the average weight was identical to that of mice heterozygous only for Sim1tm1Fan
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nervous system
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• paraventricular nucleus and supraoptic nuclei are hypocellular
• the phenotype is identical to that of mice heterozygous only for Sim1tm1Fan
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
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nervous system
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• at E18.5, the principal mammillary axonal tract appears thin and the mammilothalmic tract is undetectable
• most mammillary body axons are directed towards the midline with some becoming splayed and others forming a bundle that crosses the midline ventrally
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
|
|
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nervous system
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• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1tm1Fan alone
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
|
|
|
nervous system
|
• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1tm1Fan alone
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Jlmd mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
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nervous system
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• at E18.5, the principal mammillary axonal tract and mammilothalmic tract are absent
• on the mammillary body in the location of the principal mammillary axonal tract a group of ectopic axons is seen and at the most posterior level of the mammillary body these axons cross the midline ventrocaudally to the third ventricle
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim1tm1Jlmd mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
|
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nervous system
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• at E11.5 mammillary body axon bundles are not detectable
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