Mouse Genome Informatics
cx1
    Sim1tm1Fan/Sim1+
Sim2tm1Fan/Sim2+

involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• after 7 months the average weight was identical to that of mice heterozygous only for Sim1tm1Fan

nervous system
• paraventricular nucleus and supraoptic nuclei are hypocellular
• the phenotype is identical to that of mice heterozygous only for Sim1tm1Fan

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:76787


Mouse Genome Informatics
cx2
    Sim1tm1Fan/Sim1tm1Fan
Sim2tm1Fan/Sim2tm1Fan

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at E18.5, the principal mammillary axonal tract appears thin and the mammilothalmic tract is undetectable
• most mammillary body axons are directed towards the midline with some becoming splayed and others forming a bundle that crosses the midline ventrally


Mouse Genome Informatics
cx3
    Sim1tm1Fan/Sim1tm1Fan
Sim2tm1Fan/Sim2+

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1tm1Fan alone


Mouse Genome Informatics
cx4
    Sim1tm1Fan/Sim1+
Sim2tm1Fan/Sim2tm1Fan

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1tm1Fan alone


Mouse Genome Informatics
cx5
    Sim1tm1Jlmd/Sim1tm1Jlmd
Sim2tm1Fan/Sim2tm1Fan

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at E18.5, the principal mammillary axonal tract and mammilothalmic tract are absent
• on the mammillary body in the location of the principal mammillary axonal tract a group of ectopic axons is seen and at the most posterior level of the mammillary body these axons cross the midline ventrocaudally to the third ventricle


Mouse Genome Informatics
cx6
    Sim1tm1Fan/Sim1tm1Jlmd
Sim2tm1Fan/Sim2tm1Fan

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at E11.5 mammillary body axon bundles are not detectable