About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd22tm1Msn
targeted mutation 1, Michael S Neuberger
MGI:2180701
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd22tm1Msn/Cd22tm1Msn either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J) MGI:4354508


Genotype
MGI:4354508
hm1
Allelic
Composition
Cd22tm1Msn/Cd22tm1Msn
Genetic
Background
either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Msn mutation (0 available); any Cd22 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced life expectancy
• 9 of 43 mice die between 7 and 15 months of age

immune system
• spleens are depleted of IgMhi, IgDhi B cells
• ncreased numbers of IgMlo, IgDhi B cells in the spleen
• B1 cell population in the peritoneum is doubled
• calcium flux in B cells responds more quickly to B cell receptor binding
• elevated activation of B cells in un-immunized mice
• augmented response to T-cell dependent antigens
• 50% of mice show elevated levels of multiple IgG subclasses
• by 18 months, 70% of mice have shown high titers of anti-DNA IgG (also 30% of heterozygotes at 12 months)
• in 80% of autoimmune mice
• elevated by 5 months (J:76974)
• high titers particularly after 8 months (J:76975)

hematopoietic system
• spleens are depleted of IgMhi, IgDhi B cells
• ncreased numbers of IgMlo, IgDhi B cells in the spleen
• B1 cell population in the peritoneum is doubled
• calcium flux in B cells responds more quickly to B cell receptor binding
• elevated activation of B cells in un-immunized mice
• augmented response to T-cell dependent antigens
• 50% of mice show elevated levels of multiple IgG subclasses
• by 18 months, 70% of mice have shown high titers of anti-DNA IgG (also 30% of heterozygotes at 12 months)
• in 80% of autoimmune mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/04/2020
MGI 6.15
The Jackson Laboratory