Analysis Tools
immune system
| N |
• susceptibility to Citrobacter rodentium infection is similar to wild-type controls
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Allele Symbol Allele Name Allele ID |
Tnfsf14tm1Lpc targeted mutation 1, Lieping Chen MGI:2180198 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• susceptibility to Citrobacter rodentium infection is similar to wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• there is a decrease of about a third in the number of CD8+ T cells that activate and proliferate in response to S. aureus superantigen
• production of IFN-gamma and TNF is impaired
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• cytolytic activity is reduced by half to a third in vitro
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• IFN-gamma secretion by activated CD8+ T cells is impaired in vitro
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• TNF secretion by activated CD8+ T cells is impaired in vitro
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• mice are resistant to a hepatitis model induced by injections of concanavalin A (ConA)
• less than 10% of mice die after a lethal dose of ConA compared to 80% of control mice
• mice are also resistant to a second hepatitis model induced by Listeria monocytogenes infection with half the mice alive 200 hours after infection compared to less than 10% of controls
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• there is a decrease of about a third in the number of CD8+ T cells that activate and proliferate in response to S. aureus superantigen
• production of IFN-gamma and TNF is impaired
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• cytolytic activity is reduced by half to a third in vitro
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more disorganized medullary thymic epithelial cells than in Ltatm1Dch homozygotes
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• smaller than in Ltatm1Dch homozygotes
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• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice
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• more disorganized medullary thymic epithelial cells than in Ltatm1Dch homozygotes
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• smaller than in Ltatm1Dch homozygotes
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• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice
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• more disorganized medullary thymic epithelial cells than in Ltatm1Dch homozygotes
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• smaller than in Ltatm1Dch homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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