Phenotypes associated with this allele

• Allele Symbol: Adh1^tm2Gdu
• Allele Name: targeted mutation 2, Gregg Duester
• Allele ID: MGI:2180099
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adh1^tm2Gdu/Adh1^tm2Gdu	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3845828
cx2	Adh1^tm2Gdu/Adh1^tm2Gdu Adh7^tm1Gdu/Adh7^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3845829

Genotype
MGI:3845828

hm1

• Allelic Composition: Adh1^tm2Gdu/Adh1^tm2Gdu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:76055 )

• mice exposed to vitamin A deficiency in utero start dying during the postnatal period with all mice dead by 15 days of age

• retinol toxicity is increased in these mice with a LD50 that is 3-fold less than controls

• female mice given chow with 10-fold higher than normal amounts of vitamin A give birth to pups with high (64%) mortality in the first three days

homeostasis/metabolism

abnormal retinol metabolism ( J:76055 )

• following administration of a 50-mg/kg dose of retinol, there is a 10-fold decrease in retinoic acid production in the liver and a 23-fold drop in the sera compared to wild-type mice

• retinol toxicity is increased in these mice with a LD50 that is 3-fold less than controls

growth/size/body

weight loss ( J:76055 )

• mice exposed to vitamin A deficiency in utero have bodyweight that deviate downward from WT at 4 days of age

• body weights beyond 3 g were not achieved before death

Genotype
MGI:3845829

cx2

• Allelic Composition: Adh1^tm2Gdu/Adh1^tm2Gdu; Adh7^tm1Gdu/Adh7^tm1Gdu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:76055 )

• mice exposed to vitamin A deficiency in utero start dying during the postnatal period with all mice dead by 25 days of age

homeostasis/metabolism

abnormal retinol metabolism ( J:76055 )

• following administration of a 50-mg/kg dose of retinol, there is a 10-fold decrease in retinoic acid production in the liver and a 23-fold drop in the sera compared to wild-type mice

• retinol toxicity is increased in these mice with a LD50 that is 2.2-fold less than controls

growth/size/body

weight loss ( J:76055 )

• mice exposed to vitamin A deficiency in utero have bodyweight that deviate downward from WT at 8 days of age

• body weights beyond 6 g were not achieved before death