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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnah5Tg1Htz
transgene insertion 1, Nathaniel Heintz
MGI:2180081
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dnah5Tg1Htz/Dnah5Tg1Htz involves: C57BL/6 * CBA/J MGI:3624520


Genotype
MGI:3624520
hm1
Allelic
Composition
Dnah5Tg1Htz/Dnah5Tg1Htz
Genetic
Background
involves: C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnah5Tg1Htz mutation (0 available); any Dnah5 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die during the first 2-3 weeks of life (J:76189)
• most die during the first 2-3 weeks of life (J:76189)

respiratory system
• nasal epithelium cilia are immotile and lack dynein outer arms (J:76189)
• nasal epithelium cilia are immotile and lack dynein outer arms (J:76189)
• paranasal sinuses show excess mucus containing numerous white blood cells (J:76189)
• paranasal sinuses show excess mucus containing numerous white blood cells (J:76189)

nervous system
• seen as early as 3-5 days after birth and develops to severe enlargement of the lateral ventricles leading to thinning of the cerebral cortex, multiple hemorrhages, and compression of the cerebellum (J:76189)
• seen as early as 3-5 days after birth and develops to severe enlargement of the lateral ventricles leading to thinning of the cerebral cortex, multiple hemorrhages, and compression of the cerebellum (J:76189)
• severe enlargement of the lateral ventricles (J:76189)
• severe enlargement of the lateral ventricles (J:76189)
• hydroencephalus leads to thinning of the cerebral cortex (J:76189)
• hydroencephalus leads to thinning of the cerebral cortex (J:76189)
• compression and atrophy of the cerebellum (J:76189)
• compression and atrophy of the cerebellum (J:76189)

growth/size/body
• mutants exhibit either complete (both dextrocardia and reversal of the abdominal organs), partial, or no situs inversus (J:76189)
• mutants exhibit either complete (both dextrocardia and reversal of the abdominal organs), partial, or no situs inversus (J:76189)

craniofacial
• skull is expanded (J:76189)
• skull is expanded (J:76189)

hearing/vestibular/ear
• fail to respond to noise (J:76189)
• fail to respond to noise (J:76189)
• examination of the middle ear shows severe infection in the timpanic cavity (J:76189)
• examination of the middle ear shows severe infection in the timpanic cavity (J:76189)

immune system
• examination of the middle ear shows severe infection in the timpanic cavity (J:76189)
• examination of the middle ear shows severe infection in the timpanic cavity (J:76189)
• paranasal sinuses show excess mucus containing numerous white blood cells (J:76189)
• paranasal sinuses show excess mucus containing numerous white blood cells (J:76189)

behavior/neurological

skeleton
• skull is expanded (J:76189)
• skull is expanded (J:76189)

cellular
• nasal epithelium cilia are immotile and lack dynein outer arms (J:76189)
• nasal epithelium cilia are immotile and lack dynein outer arms (J:76189)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory