Phenotypes associated with this allele

• Allele Symbol: Tff2^tm1Tcw
• Allele Name: targeted mutation 1, Timothy C Wang
• Allele ID: MGI:2179101
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tff2^tm1Tcw/Tff2^tm1Tcw	involves: 129S4/SvJae * C57BL/6	MGI:3028981

Genotype
MGI:3028981

hm1

• Allelic Composition: Tff2^tm1Tcw/Tff2^tm1Tcw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:74338 )

• reduced glandular cell count

• reduced gland height

abnormal stomach morphology ( J:74338 )

abnormal stomach mucosa morphology ( J:74338 )

• reduced thickness

• reduced proliferation

• reduced pit size

excessive digestive secretion ( J:74338 )

• increased basal and stimulated gastic acid output

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:74338 )

• reduced glandular cell count

• reduced gland height

homeostasis/metabolism

increased susceptibility to injury ( J:74338 )

• increased gastric ulceration after indomethacin administration

• no increase in gastric, duodenal, or small intestinal ulceration under basal conditions