All Phenotypes Tcf3<tm1Wein> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcf3^tm1Wein
targeted mutation 1, Harold Weintraub
MGI:2178112

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf3^tm1Wein/Tcf3^tm1Wein	either: (involves: 129 * 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:2682876
hm2	Tcf3^tm1Wein/Tcf3^tm1Wein	involves: 129S4/SvJaeSor	MGI:3776844
hm3	Tcf3^tm1Wein/Tcf3^tm1Wein	involves: 129S4/SvJaeSor * C57BL/6	MGI:5000524
ht4	Tcf3^tm1Wein/Tcf3⁺	either: (involves: 129/Sv * 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:2680064
ht5	Tcf3^tm1Wein/Tcf3⁺	involves: 129S4/SvJaeSor	MGI:3046427
ht6	Tcf3^tm1Wein/Tcf3^tm3Zhu	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6	MGI:3776846
cx7	Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Wein/Tcf3⁺	involves: 129P2/OlaHsd	MGI:3040600
cx8	Id1^tm1Zhu/Id1^tm1Zhu Tcf3^tm1Wein/Tcf3^tm1Wein	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:5000525
cx9	Tcf12^tm1Zhu/Tcf12⁺ Tcf3^tm1Wein/Tcf3⁺	involves: 129S4/SvJaeSor	MGI:3040599

Allelic Composition	Tcf3^tm1Wein/Tcf3^tm1Wein
Genetic Background	either: (involves: 129 * 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:22134 )

• pups appear normal at birth

• homozygotes usually die before weaning, most frequently in the first week

• death is preceded by cessation of growth, weight loss, and dehydration

growth/size/body

postnatal growth retardation ( J:22134 )

• growth is slower than normal, but appetite and feeding seems normal

• females are more severely affected than males

hematopoietic system

abnormal lymphocyte cell number ( J:22134 )

• the population of double positive CD4/CD8 cells in thymus gradually becomes reduced in 2-3 week old mice

abnormal B cell number ( J:22134 )

• absence of B cells and precursors in E18.5 livers

• few or no B220 positive cells are present in bone marrow or spleen

• no IgM positive cells are found

spleen atrophy ( J:22134 )

• spleen degenerates in first three weeks of life

immune system

abnormal lymphocyte cell number ( J:22134 )

• the population of double positive CD4/CD8 cells in thymus gradually becomes reduced in 2-3 week old mice

abnormal B cell number ( J:22134 )

• absence of B cells and precursors in E18.5 livers

• few or no B220 positive cells are present in bone marrow or spleen

• no IgM positive cells are found

spleen atrophy ( J:22134 )

• spleen degenerates in first three weeks of life

Allelic Composition	Tcf3^tm1Wein/Tcf3^tm1Wein
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:47671 )

Allelic Composition	Tcf3^tm1Wein/Tcf3^tm1Wein
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:44278 )

• a small number of homozygous mice survive to about 10 months

neonatal lethality, incomplete penetrance ( J:44278 )

neoplasm

increased T cell derived lymphoma incidence ( J:44278 )

• mice developing tumors were hunchbacked, skinny, and physically weak

• tumor cells found in blood, lymphoid, and non lymphoid organs

• tumor cells either lacked T-cell receptors or had only low levels

immune system

enlarged thymus ( J:44278 )

hematopoietic system

enlarged thymus ( J:44278 )

endocrine/exocrine glands

enlarged thymus ( J:44278 )

increased T cell derived lymphoma incidence ( J:44278 )

• mice developing tumors were hunchbacked, skinny, and physically weak

• tumor cells found in blood, lymphoid, and non lymphoid organs

• tumor cells either lacked T-cell receptors or had only low levels

Allelic Composition	Tcf3^tm1Wein/Tcf3⁺
Genetic Background	either: (involves: 129/Sv * 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:22134 )

• B cell numbers reduced by half in the spleen but not the bone marrow

immune system

decreased B cell number ( J:22134 )

• B cell numbers reduced by half in the spleen but not the bone marrow

Allelic Composition	Tcf3^tm1Wein/Tcf3⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell number ( J:91042 )

• the IgM⁺IgD^- cell population is significantly reduced

• the IgM⁺IgD⁺ cell population is increased in the bone marrow

• the fraction of B cells expressing Ig-lambda is reduced

decreased pre-B cell number ( J:91042 )

• the fraction of pre-B cells is reduced about 2 fold

immune system

abnormal B cell number ( J:91042 )

• the IgM⁺IgD^- cell population is significantly reduced

• the IgM⁺IgD⁺ cell population is increased in the bone marrow

• the fraction of B cells expressing Ig-lambda is reduced

decreased pre-B cell number ( J:91042 )

• the fraction of pre-B cells is reduced about 2 fold

Allelic Composition	Tcf3^tm1Wein/Tcf3^tm3Zhu
Genetic Background	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)
Tcf3^tm3Zhu mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:47671 )

• postnatal survival is lower than normal but improved compared to Tcfe2a null mice

hematopoietic system

decreased pro-B cell number ( J:47671 )

immune system

decreased pro-B cell number ( J:47671 )

Allelic Composition	Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Wein/Tcf3⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)
Tcf4^tm1Zhu mutation (1 available); any Tcf4 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:43324 )

• most homozygotes died within two weeks of birth

growth/size/body

postnatal growth retardation ( J:43324 )

• evident after birth

hematopoietic system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

immune system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

Allelic Composition	Id1^tm1Zhu/Id1^tm1Zhu Tcf3^tm1Wein/Tcf3^tm1Wein
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1^tm1Zhu mutation (0 available); any Id1 mutation (8 available)
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:44278 )

• neonatal lethality observed in Tcf3^tm1Wein homozygotes is partially rescued

postnatal lethality, incomplete penetrance ( J:44278 )

• while fewer than expected mice are present at weaning, survival at weaning compared with Tcf3^tm1Wein homozygotes is improved

immune system

abnormal thymus corticomedullary boundary morphology ( J:44278 )

• completely effaced by large immature lymphoblastic cells

arrested B cell differentiation ( J:44278 )

• B cell development is blocked at the pro-B cell stage with no B220^dull CD43+ cells detected in E18.5 fetal livers unlike in wild-type mice

decreased lymphocyte cell number ( J:44278 )

• the lymphocyte population in the bone marrow is decreased compared to in wild-type mice

absent B cells ( J:44278 )

• in the bone marrow

intermingled spleen red and white pulp ( J:44278 )

• due to large immature lymphoblastic cells

neoplasm

increased T cell derived lymphoma incidence ( J:44278 )

• after 3 months, all mice develop T cell tumors unlike in Id1^tm1Zhu homozygotes

• tumors infiltrate the liver, pancreas, and kidney

growth/size/body

postnatal growth retardation ( J:44278 )

hematopoietic system

abnormal thymus corticomedullary boundary morphology ( J:44278 )

• completely effaced by large immature lymphoblastic cells

arrested B cell differentiation ( J:44278 )

• B cell development is blocked at the pro-B cell stage with no B220^dull CD43+ cells detected in E18.5 fetal livers unlike in wild-type mice

decreased lymphocyte cell number ( J:44278 )

• the lymphocyte population in the bone marrow is decreased compared to in wild-type mice

absent B cells ( J:44278 )

• in the bone marrow

intermingled spleen red and white pulp ( J:44278 )

• due to large immature lymphoblastic cells

endocrine/exocrine glands

abnormal thymus corticomedullary boundary morphology ( J:44278 )

• completely effaced by large immature lymphoblastic cells

increased T cell derived lymphoma incidence ( J:44278 )

• after 3 months, all mice develop T cell tumors unlike in Id1^tm1Zhu homozygotes

• tumors infiltrate the liver, pancreas, and kidney

Allelic Composition	Tcf12^tm1Zhu/Tcf12⁺ Tcf3^tm1Wein/Tcf3⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12^tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:43324 )

• most homozygotes died within two weeks of birth

growth/size/body

postnatal growth retardation ( J:43324 )

• evident after birth

hematopoietic system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

immune system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

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