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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nyxnob
no b wave
MGI:2177945
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nyxnob/Nyxnob BALB/c-Nyxnob MGI:3055970
hm2
Nyxnob/Nyxnob involves: BALB/cGr MGI:3720062
ht3
Nyxnob/Nyx+ involves: BALB/cGr MGI:5568984
ot4
Nyxnob/Y involves: BALB/cGr MGI:3720065


Genotype
MGI:3055970
hm1
Allelic
Composition
Nyxnob/Nyxnob
Genetic
Background
BALB/c-Nyxnob
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nyxnob mutation (0 available); any Nyx mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• does not display electroretinographic (ERG) b-waves
• ERG finding is observed by day 18
• light-adapted cone ERG retains a negative polarity
• dark-adapted rod ERG retains a negative polarity even with increasing stimulus intensity
• no response to visual evoked potential at flash onset and slight response at flash offset
• decreased light sensitivity

Mouse Models of Human Disease
OMIM ID Ref(s)
Night Blindness, Congenital Stationary, Type 1A; CSNB1A 310500 J:50824




Genotype
MGI:3720062
hm2
Allelic
Composition
Nyxnob/Nyxnob
Genetic
Background
involves: BALB/cGr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nyxnob mutation (0 available); any Nyx mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• light adapted ERG is reduced in amplitude and has slower kinetics as compared to control
• implicit time of the b-wave is delayed
• cone ERG amplitude has a distinctive waveform as compared to control
• b-wave is absent in dark-adapted electroretinogram (ERG)




Genotype
MGI:5568984
ht3
Allelic
Composition
Nyxnob/Nyx+
Genetic
Background
involves: BALB/cGr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nyxnob mutation (0 available); any Nyx mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• reduced b-wave in dark-adapted mice




Genotype
MGI:3720065
ot4
Allelic
Composition
Nyxnob/Y
Genetic
Background
involves: BALB/cGr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nyxnob mutation (0 available); any Nyx mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• implicit time of the b-wave is delayed
• light adapted ERG is reduced in amplitude and has slower kinetics as compared to control
• cone ERG amplitude has a distinctive waveform as compared to control
• b-wave is absent in dark-adapted electroretinogram (ERG)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory