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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre)1Lfr
transgene insertion 1, Louis F Reichardt
MGI:2177631
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Camk2a-cre)1Lfr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:2177642
cn2
Ntrk2tm1Lfr/Ntrk2tm1Lfr
Tg(Camk2a-cre)1Lfr/0
involves: 129X1/SvJ * C57BL/6 * DBA MGI:2450114


Genotype
MGI:2177642
cn1
Allelic
Composition
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Camk2a-cre)1Lfr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfamtm1Lrsn mutation (0 available); any Tfam mutation (4 available)
Tg(Camk2a-cre)1Lfr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 5-6 months of age, preceded by 1-2 weeks of rapid physical deterioration

nervous system
• in corpus callosum, hippocampus; progressive with age
• degeneration of cortical organization in neocortex
• neuronal apoptosis in neocortex and hippocampus; progressive with age

cellular
• resipratory chain dysfunction in neurons of the neocortex and hippocampus




Genotype
MGI:2450114
cn2
Allelic
Composition
Ntrk2tm1Lfr/Ntrk2tm1Lfr
Tg(Camk2a-cre)1Lfr/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Lfr mutation (1 available); any Ntrk2 mutation (35 available)
Tg(Camk2a-cre)1Lfr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• severe compression of layers II/III and layer V of the visual cortex
• mice exhibit a loss of Pou3f1-expressing neurons
• neuron cell bodies exhibit a 27% reduction in size with round morphology
• dendrites are thin and exhibit reduced complexity
• primary dendrites possess fewer and/or shorter branches
• the average apical diameter of a dendrite is reduced by 41% compared to in heterozygotes
• mice exhibit a loss of Pou3f1-expressing neurons





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory