• at 5-6 months of age, preceded by 1-2 weeks of rapid physical deterioration

• in corpus callosum, hippocampus; progressive with age

• degeneration of cortical organization in neocortex

• neuronal apoptosis in neocortex and hippocampus; progressive with age

• resipratory chain dysfunction in neurons of the neocortex and hippocampus

• compression occurs

• severe compression of layers II/III and layer V of the visual cortex

• mice exhibit a loss of Pou3f1-expressing neurons

• neuron cell bodies exhibit a 27% reduction in size with round morphology

• dendrites are thin and exhibit reduced complexity

• primary dendrites possess fewer and/or shorter branches

• the average apical diameter of a dendrite is reduced by 41% compared to in heterozygotes

• mice exhibit a loss of Pou3f1-expressing neurons