Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4tm1.1Frk mutation
(2 available);
any
Celf4 mutation
(27 available)
Tg(Camk2a-cre)1Lfr mutation
(2 available)
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behavior/neurological
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• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females
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nervous system
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• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfamtm1Lrsn mutation
(1 available);
any
Tfam mutation
(11 available)
Tg(Camk2a-cre)1Lfr mutation
(2 available)
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mortality/aging
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• at 5-6 months of age, preceded by 1-2 weeks of rapid physical deterioration
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nervous system
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• in corpus callosum, hippocampus; progressive with age
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• degeneration of cortical organization in neocortex
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• neuronal apoptosis in neocortex and hippocampus; progressive with age
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cellular
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• resipratory chain dysfunction in neurons of the neocortex and hippocampus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Lfr mutation
(2 available);
any
Ntrk2 mutation
(66 available)
Tg(Camk2a-cre)1Lfr mutation
(2 available)
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nervous system
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• severe compression of layers II/III and layer V of the visual cortex
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• mice exhibit a loss of Pou3f1-expressing neurons
• neuron cell bodies exhibit a 27% reduction in size with round morphology
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• dendrites are thin and exhibit reduced complexity
• primary dendrites possess fewer and/or shorter branches
• the average apical diameter of a dendrite is reduced by 41% compared to in heterozygotes
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• mice exhibit a loss of Pou3f1-expressing neurons
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Analysis Tools