Mouse Genome Informatics
cn1
    Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Camk2a-cre)1Lfr/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• at 5-6 months of age, preceded by 1-2 weeks of rapid physical deterioration

nervous system
• in corpus callosum, hippocampus; progressive with age
• degeneration of cortical organization in neocortex
• neuronal apoptosis in neocortex and hippocampus; progressive with age

cellular
• resipratory chain dysfunction in neurons of the neocortex and hippocampus


Mouse Genome Informatics
cn2
    Ntrk2tm1Lfr/Ntrk2tm1Lfr
Tg(Camk2a-cre)1Lfr/0

involves: 129X1/SvJ * C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• severe compression of layers II/III and layer V of the visual cortex
• mice exhibit a loss of Pou3f1-expressing neurons
• neuron cell bodies exhibit a 27% reduction in size with round morphology
• dendrites are thin and exhibit reduced complexity
• primary dendrites possess fewer and/or shorter branches
• the average apical diameter of a dendrite is reduced by 41% compared to in heterozygotes
• mice exhibit a loss of Pou3f1-expressing neurons