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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Leprtm1Rck
targeted mutation 1, Jeffrey M Friedman
MGI:2176774
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Leprtm1Rck/Leprtm1Rck involves: 129/Sv MGI:2182821
cn2
Leprtm1Rck/Leprtm1.1Rck
Tg(Alb1-cre)1Rck/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:2176781
cn3
Leprtm1Rck/Leprtm1.1Rck
Tg(Syn1-cre)671Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:2176782


Genotype
MGI:2182821
hm1
Allelic
Composition
Leprtm1Rck/Leprtm1Rck
Genetic
Background
involves: 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1Rck mutation (1 available); any Lepr mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2176781
cn2
Allelic
Composition
Leprtm1Rck/Leprtm1.1Rck
Tg(Alb1-cre)1Rck/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Rck mutation (1 available); any Lepr mutation (65 available)
Leprtm1Rck mutation (1 available); any Lepr mutation (65 available)
Tg(Alb1-cre)1Rck mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• normal body weight, normal amounts of adipose tissue, normal clinical chemistry and normal liver




Genotype
MGI:2176782
cn3
Allelic
Composition
Leprtm1Rck/Leprtm1.1Rck
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Rck mutation (1 available); any Lepr mutation (65 available)
Leprtm1Rck mutation (1 available); any Lepr mutation (65 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

growth/size/body
• increased adipose tissue mass and decreased lean tissue mass
• observed after 5 weeks of age

homeostasis/metabolism
• 2.3 fold greater plasma glucose levels in females compared to littermates; males normal
• hyperinsulinemia; 6 fold greater plasma insulin levels in males and 16.1 fold greater levels in females compared to littermates
• 5.8 fold greater in males and 8.3 fold greater in females compared to littermates

liver/biliary system
• enlarged liver due to fatty deposits





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory