Mouse Genome Informatics
hm1
     Leprtm1Rck/Leprtm1Rck
involves: 129/Sv
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype


Mouse Genome Informatics
cn2
     Leprtm1Rck/Leprtm1.1Rck
Tg(Alb1-cre)1Rck/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:72241 )
• normal body weight, normal amounts of adipose tissue, normal clinical chemistry and normal liver


Mouse Genome Informatics
cn3
     Leprtm1Rck/Leprtm1.1Rck
Tg(Syn1-cre)671Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
adipose tissue

growth/size
increased body weight ( J:72241 )
• observed after 5 weeks of age

homeostasis/metabolism
hyperglycemia ( J:72241 )
• 2.3 fold greater plasma glucose levels in females compared to littermates; males normal
increased circulating insulin level ( J:72241 )
• hyperinsulinemia; 6 fold greater plasma insulin levels in males and 16.1 fold greater levels in females compared to littermates
increased circulating leptin level ( J:72241 )
• 5.8 fold greater in males and 8.3 fold greater in females compared to littermates
abnormal body composition ( J:72241 )
• increased adipose tissue mass and decreased lean tissue mass

liver/biliary system
hepatic steatosis ( J:72241 )
• enlarged liver due to fatty deposits