Mouse Genome Informatics
hm1
    Leprtm1Rck/Leprtm1Rck
involves: 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype


Mouse Genome Informatics
cn2
    Leprtm1Rck/Leprtm1.1Rck
Tg(Alb1-cre)1Rck/0

involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• normal body weight, normal amounts of adipose tissue, normal clinical chemistry and normal liver


Mouse Genome Informatics
cn3
    Leprtm1Rck/Leprtm1.1Rck
Tg(Syn1-cre)671Jxm/0

involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
adipose tissue

growth/size
• increased adipose tissue mass and decreased lean tissue mass
• observed after 5 weeks of age

homeostasis/metabolism
• 2.3 fold greater plasma glucose levels in females compared to littermates; males normal
• hyperinsulinemia; 6 fold greater plasma insulin levels in males and 16.1 fold greater levels in females compared to littermates
• 5.8 fold greater in males and 8.3 fold greater in females compared to littermates

liver/biliary system
• enlarged liver due to fatty deposits