Phenotypes associated with this allele

• Allele Symbol: Fhit^tm1Hbn
• Allele Name: targeted mutation 1, Kay Huebner
• Allele ID: MGI:2176611
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fhit^tm1Hbn/Fhit^tm1Hbn	involves: 129X1/SvJ * C57BL/6	MGI:3029764
ht2	Fhit^tm1Hbn/Fhit^+	involves: 129X1/SvJ * C57BL/6	MGI:3029765
cx3	Fhit^tm1Hbn/Fhit^tm1Hbn Hint1^tm1.1Tpm/Hint1^tm1.1Tpm	involves: 129X1/SvJ * BALB/c * C57BL/6	MGI:2663686
cx4	Fhit^tm1Hbn/Fhit^tm1Hbn Hint1^tm1.1Tpm/Hint1^+	involves: 129X1/SvJ * BALB/c * C57BL/6	MGI:2663691

Genotype
MGI:3029764

hm1

• Allelic Composition: Fhit^tm1Hbn/Fhit^tm1Hbn
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:71303 )

• 29% of heterozygous mice were found dead before normal life span with evidence of widespread infections

neoplasm

increased tumor incidence ( J:71303 )

• in untreated mice, the incidence of spontaneous tumors of various types was 53%

increased incidence of tumors by chemical induction ( J:71303 )

• 89% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract

hematopoietic system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

immune system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

increased susceptibility to infection ( J:71303 )

• mice exhibit evidence of widespread infections and abcesses

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:71303 )

• 89% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract

Genotype
MGI:3029765

ht2

• Allelic Composition: Fhit^tm1Hbn/Fhit⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

mortality/aging

premature death ( J:71303 )

• 26% of heterozygous mice were found dead before normal life span with evidence of widespread infections

neoplasm

increased tumor incidence ( J:71303 )

• in untreated mice, the incidence of spontaneous tumors of various types was 53%

increased incidence of tumors by chemical induction ( J:61946 , J:71303 , J:110096 )

• 10 weeks after NMBA treatment, all heterozygous mice exhibited tumors in various tissues, especially the gastrointestinal tract including the forestomach and squamocolumnar juction; the incidence of tumors in control mice was 25% (J:61946)

• 78% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract (J:71303)

• mutants develop preneoplastic lesions of the uterus more frequently than wild-type after multiple doses of benzol[a]pyrene (B[a]P), however develop similar levels of forestomach and lung tumors (J:110096)

hematopoietic system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

immune system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

increased susceptibility to infection ( J:71303 )

• mice exhibit evidence of widespread infections and abcesses

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:61946 , J:71303 , J:110096 )

• 10 weeks after NMBA treatment, all heterozygous mice exhibited tumors in various tissues, especially the gastrointestinal tract including the forestomach and squamocolumnar juction; the incidence of tumors in control mice was 25% (J:61946)

• 78% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract (J:71303)

• mutants develop preneoplastic lesions of the uterus more frequently than wild-type after multiple doses of benzol[a]pyrene (B[a]P), however develop similar levels of forestomach and lung tumors (J:110096)

integument

alopecia ( J:110096 )

• spontaneous alopecia areata and hair bulb cell apoptosis are greatly accelerated in mutants compared to wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Muir-Torre syndrome		DOID:0050465	OMIM:158320	J:61946

Genotype
MGI:2663686

cx3

• Allelic Composition: Fhit^tm1Hbn/Fhit^tm1Hbn; Hint1^tm1.1Tpm/Hint1^tm1.1Tpm
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

neoplasm

increased tumor incidence ( J:83562 )

• a small number of extraintestinal tumors and neoplasias were observed; spectrum was similar to that noted in Fhit deficient mice

Genotype
MGI:2663691

cx4

• Allelic Composition: Fhit^tm1Hbn/Fhit^tm1Hbn; Hint1^tm1.1Tpm/Hint1⁺
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

neoplasm

increased tumor incidence ( J:83562 )

• a small number of extraintestinal tumors and neoplasias were observed; spectrum was similar to that noted in Fhit deficient mice