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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plin1tm1Chan
targeted mutation 1, Lawrence Chan
MGI:2176248
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plin1tm1Chan/Plin1tm1Chan involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3839677
cx2
Leprdb/Leprdb
Plin1tm1Chan/Plin1tm1Chan
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J MGI:3839678


Genotype
MGI:3839677
hm1
Allelic
Composition
Plin1tm1Chan/Plin1tm1Chan
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plin1tm1Chan mutation (1 available); any Plin1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• total fat content of mice is 58% less while protein content is 21% higher than in controls
• mice are resistant to obesity caused by eating a high-fat diet for 3.5 months with total fat content being 50% less than controls

adipose tissue
• subcutaneous fat weight is about half that of controls
• total fat content of mice is 58% less than controls
• MRI analysis finds total adipocyte content is 36% less than controls
• lipid droplet size in brown fat cells is much smaller than in controls
• white fat cell size is 62% smaller than controls
• epididymal fat pads weigh about 4-fold less than controls
• interscapular fat pads weight about half that of controls
• fat pads weigh 37%-74% less than controls

behavior/neurological
• mice consume 0.429 kcal/day/g body weight compared to 0.332 kcal/day/g body weight for controls

homeostasis/metabolism
• mice are resistant to obesity caused by eating a high-fat diet for 3.5 months with total fat content being 50% less than controls
• fasted mice drop body temperature much more quickly than controls in response to a cold environment
• mice have decreased levels of circulating leptins with males having 2.26 ng/ml versus 3.64 ng/ml in controls, and female mice having 1.78 ng/ml versus 3.02 ng/ml for controls
• rises in ketone bodies caused be fasting are attenuated in these mice
• non-esterified free fatty acids (NEFA) do not increase in circulation after fasting compared to a doubling in level that occurs to controls
• NEFA levels also do not increase in response to isoproterenol treatment
• mice on a regular chow diet consume 11% more oxygen than controls
• mice fed a high fat diet consume 20% more oxygen than diet-matched controls
• rises in glycerol in response to beta-adrenergic agonists are attenuated in these mice
• lipase activity of subcutaneous fat extracts is 287% greater than controls and extracts from epididymal fat is 652% greater than controls
• rises in glycerol or NEFA levels in response to beta-adrenergic agonists is attenuated compared to controls suggesting that adipocytes have near-maximal lipolysis under basal conditions

muscle
• gastrocnemius muscle of mutants weighs 7.8% more than that of controls

integument
• subcutaneous fat weight is about half that of controls




Genotype
MGI:3839678
cx2
Allelic
Composition
Leprdb/Leprdb
Plin1tm1Chan/Plin1tm1Chan
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprdb mutation (15 available); any Lepr mutation (90 available)
Plin1tm1Chan mutation (1 available); any Plin1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice are resistant to the obesity caused by the Leprdb background
• at a given age, mice weigh significantly less than Leprdb homozygotes but more than wild-type controls
• MRI analysis finds the total lipid signal for these mice at 27% compared to 24% for wild-type and 63% for the Leprdb homozygotes

homeostasis/metabolism
• mice have much higher rates of oxygen consumption compared to controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory