Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mas1tm1Bdr mutation
(1 available);
any
Mas1 mutation
(23 available)
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nervous system
N |
• mice exhibit normal cell numbers in the hippocampus and thalamus
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• in the dentate gyrus
• rebound in potentiation after low frequency stimulation which does not occur in controls
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behavior/neurological
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• higher anxiety response seen in elevated-plus maze tests
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mas1tm1Bdr mutation
(1 available);
any
Mas1 mutation
(23 available)
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renal/urinary system
N |
• at 9-10 weeks of age, kidney weight, cortical tubule diameter, and Bowman's space diameter remain normal
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• renal blood flow is significantly reduced
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• total renal vascular resistance is significantly increased
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• fractional excretion of sodium is significantly reduced
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• urinary osmolality is significantly increased
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• urinary albumin excretion is significantly elevated
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• Bowman's capsule diameter is significantly reduced
• however, Bowman's space diameter remains normal
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• glomerulus tuft diameter is significantly reduced
• however, no glomerular hypertrophy is observed
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• increased expression of collagen IV and fibronectin in the mesangium
• however, normal expression of collagen types I and III in the mesangium
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• increased expression of collagen III, collagen IV, and fibronectin in the renal interstitium (cortex and medulla)
• however, normal expression of collagen I in both cortex and medulla
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• creatinine clearance is significantly increased
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• GFR is significantly elevated (1.8-fold), as measured by creatinine and inulin clearances
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• 24-h urine flow is significantly reduced
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homeostasis/metabolism
cardiovascular system
N |
• Background Sensitivity: mean arterial pressure is normal on a C57BL/6 background
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• renal blood flow is significantly reduced
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• total renal vascular resistance is significantly increased
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behavior/neurological
N |
• no differences in water and food intake are observed
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