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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bdkrb1tm1Bdr
targeted mutation 1, Michael Bader
MGI:2158501
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bdkrb1tm1Bdr/Bdkrb1tm1Bdr involves: 129P2/OlaHsd MGI:2656216


Genotype
MGI:2656216
hm1
Allelic
Composition
Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdkrb1tm1Bdr mutation (1 available); any Bdkrb1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants showed a 50% reduction in the activity-dependent facilitation ("wind-up") of a spinal nociceptive reflex evoked by electrical stimulation of afferent nociceptive fibers
• intradermal injection of capsaicin (1.6 mg), which activates polymodal nociceptors responding to heat, evoked diminished nocifensive behaviors in mutant mice relative to wild-type
• intradermal injection of formalin (2.5%), evoked significantly reduced nocifensive behaviors in the early and late phase of the model
• in the hot plate assay, mutant mice exhibited marked hypoalgesia in response to mildly painful heat stimuli (52.5 and 55.5C); no difference was observed with more painful stimuli (58.5C)
• in the tail-flick assay, mutants displayed normal acute nociception in response to a noxious heat stimulus relative to wild-type
• in addition, the noxious heat sensitivity of two functional classes of isolated nociceptors (differentiated by their IB4 binding) appeared normal

immune system
• in the carrageenan-induced pleurisy model, invasion of polymorphonuclear leukocytes into inflamed tissue was markedly reduced; in contrast, endothelial permeabilization and mononuclear cell infiltration appeared unaffected
• mice exhibit a partially attenuated hypotensive response to LPS compared to wild-type mice

cardiovascular system
N
• homozygous mutant mice were viable, fertile and normotensive
• notably, homozygotes displayed a significant reduction in the hypotensive response to lipopolysaccharide injection (a model for sepsis) during the first 35 min but not thereafter

integument
• mutants showed a 50% reduction in the activity-dependent facilitation ("wind-up") of a spinal nociceptive reflex evoked by electrical stimulation of afferent nociceptive fibers
• intradermal injection of capsaicin (1.6 mg), which activates polymodal nociceptors responding to heat, evoked diminished nocifensive behaviors in mutant mice relative to wild-type
• intradermal injection of formalin (2.5%), evoked significantly reduced nocifensive behaviors in the early and late phase of the model
• in the hot plate assay, mutant mice exhibited marked hypoalgesia in response to mildly painful heat stimuli (52.5 and 55.5C); no difference was observed with more painful stimuli (58.5C)
• in the tail-flick assay, mutants displayed normal acute nociception in response to a noxious heat stimulus relative to wild-type
• in addition, the noxious heat sensitivity of two functional classes of isolated nociceptors (differentiated by their IB4 binding) appeared normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory