• females appear normal for the first 4 months but show ataxic gait at later ages (J:67909)

• females appear normal for the first 4 months but show hypoactivity at later ages (J:67909)

• females appear normal for the first 4 months but gain weight at later ages (J:67909)

• mutants at 10 weeks of age exhibit an abnormally high breathing frequency associated with marked decreases in expiratory time and total breath duration and a small but significant decrease in inspiratory time (J:181342)

• treatment with LM22A-4, a small molecule BDNF loop domain mimetic that acts as a selective TrkB agonist, improves the respiratory function of mutants (J:181342)

• breathing dysfunction is characterized by increased frequency due to periods of tachypnea and increased apneas (J:181342)

• 20% of mutants exhibit apneas at 8 weeks of age and by 12 weeks of age, 50% of mutants exhibit apneas (J:181342)

• number of apneas increases between 8 and 12 weeks of age in mutants (J:181342)

• mutants are severely underweight from 4-5 weeks of age (J:89593)

• 8 - 13 week old mutants display a 14-18% reduction in brain weight (J:89593)

• life span is shorter than in Mecp2 single homozygous mice (J:106973)

• dramatic reduction in wheel running activity at 4 weeks of age (J:106973)

• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls (J:106973)

• life span is shorter than in Mecp2 single hemizygous mice but longer than in mutant mice homozygous for the Bdnf allele (J:106973)

• life span is significantly longer than in Mecp2 single hemizygous mice (J:106973)

• overexpression of BDNF improves locomotor function compared to Mecp2 single hemizygous mice at 6 weeks of age (J:106973)

• decreased compared to wild-type littermates but modestly increased compared to Mecp2 single hemizygous mice (J:106973)

• firing rate is increased compared to Mecp2 single hemizygous mice (J:106973)

• mutant activity as measured by exploratory response and total nocturnal activity does not differ from wild-type mice (J:89593)

• mutants display normal body weight (J:89593)

• mutants display normal brain weight (J:89593)

• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death (J:67909)

• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age (J:67909)

• seen at 5 weeks of age (J:67909)

• exhibit body trembling at 5 weeks of age (J:67909)

• at late stages of disease, mutants tremble when handled (J:67909)

• seen at late stages of disease (J:67909)

• neurons in the CA2 region are 15-25% smaller than in controls at 9 weeks of age (J:67909)

• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed (J:67909)

• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease (J:67909)

• 8 of 17 become overweight and obese at 40-60 days of age (J:67909)

• frequently display cold extremities (J:67909)

• occasionally show heavy breathing at 5 weeks of age (J:67909)

• decrease size of CA2 neurons (J:106973)

• decreased size of the olfactory glomeruli (J:106973)

• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls (J:106973)

• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice (J:181311)

• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice (J:181311)

• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice (J:181311)

• at P90, mice exhibit less of an increase in event related phase-locking factor compared with wild-type mice (J:181311)

• in an elevated zero maze (J:181311)

• impaired motor learning on a rotarod (J:181311)

• on a rotarod (J:181311)

• develops at 6 weeks of age (J:106973)

• with splaying hind limbs upon movement (J:181311)