Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1btm1Dch mutation
(1 available);
any
Il1b mutation
(24 available)
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craniofacial
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• there is a significant increase in root resorption associated with orthodontic force on mutant's molar teeth compared to wild-type mice
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skeleton
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• there is a significant increase in root resorption associated with orthodontic force on mutant's molar teeth compared to wild-type mice
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growth/size/body
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• there is a significant increase in root resorption associated with orthodontic force on mutant's molar teeth compared to wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1btm1Dch mutation
(1 available);
any
Il1b mutation
(24 available)
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immune system
N |
• mice exposed to anthrax lethal toxin exhibit normal development of disease
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• mice show no footpad swelling after antigen challenge following sensitization with 0.1% TNCB, which generates maximal swelling in wild-type controls
• sensitization with 1% of TNCB is needed to generate the maximal response in mutant mice
• T cells isolated from draining lymph nodes fail to proliferate the TCNB to the same degree as T cells isolated from wild-type mice
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• IL-1beta is not produced in these mice
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• mice succumb to 108 CFU Salmonella infection more rapidly than controls
• there is an average 10-fold-higher bacterial loads in infected Peyer's patches, mesenteric lymph nodes, and spleens than in the infected organs of wild-type animals
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1btm1Dch mutation
(1 available);
any
Il1b mutation
(24 available)
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homeostasis/metabolism
nervous system
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• mice have defects in the regeneration of the mature oligodendrocyte population after a demyelinating insult
• after cuprizone insult, the number of oligodendrocytes present is significantly less than controls both 7 and 10 weeks after cuprizone withdrawal
• instead there is an increase oligodendrocyte precursors
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• mice treated with cuprizone to cause demyelination have defects in remyelination
• only 45% of axons are remyelinated 4 weeks after cuprizone removal compared to 67.1% in controls
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immune system
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• mice succumb more rapidly than controls to108 CFU of Salmonella with a median survival time of 6 days compared to 8 days for controls
• there is an average 30-fold-higher bacterial loads in infected Peyer's patches, mesenteric lymph nodes, and spleens than in the infected organs of wild-type animals
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