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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Aldh2tm1Kaw
targeted mutation 1, Toshihiro Kawamoto
MGI:2157245
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Aldh2tm1Kaw/Aldh2tm1Kaw involves: 129P2/OlaHsd * C57BL/6 MGI:2654875


Genotype
MGI:2654875
hm1
Allelic
Composition
Aldh2tm1Kaw/Aldh2tm1Kaw
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh2tm1Kaw mutation (2 available); any Aldh2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in vitro, mutant liver mitochondrial fractions are deficient in methoxyacetaldehyde dehydrogenase (MALD) activity

cellular
• in vitro, liver mitochondrial fractions derived from homozygous mutant mice display absence of aldehyde oxidation activity toward acetaldehyde (AALD), proprionaldehyde (PALD), and methoxyacetaldehyde (MALD)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory