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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zic1tm1Jaru
targeted mutation 1, Jun Aruga
MGI:2156822
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zic1tm1Jaru/Zic1tm1Jaru involves: 129S4/SvJae * C57BL/6J MGI:2653198
hm2
Zic1tm1Jaru/Zic1tm1Jaru involves: 129S4/SvJae * C57BL/6J * C3H/HeN MGI:2653197
ht3
Zic1tm1Jaru/Zic1+ B6.129S4-Zic1tm1Jaru MGI:3716303
ht4
Zic1tm1Jaru/Zic1+ involves: 129S4/SvJae * C57BL/6J * C3H/HeN MGI:3511206


Genotype
MGI:2653198
hm1
Allelic
Composition
Zic1tm1Jaru/Zic1tm1Jaru
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic1tm1Jaru mutation (2 available); any Zic1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice died within 1 day of birth
• remaining 50% of mice died within 3 weeks of birth

behavior/neurological
• less milk in stomach than littermate controls, authors suggest as a result of poor suckling
• authors attribute growth retardation to less milk ingestion
• extended period of time required to right self; sometimes completely unable to do so
• often lied on backs, forelimbs extended anteriorly and making irregular motions
• loss of coordinated movement of all 4 limbs
• dragged hindlimbs
• unable to walk a straight line
• most fell to one side

growth/size/body
• significantly smaller than littermate controls at P2, authors suggest due to poor suckling which resulted in decreased amounts of milk in stomach

skeleton
• in thoracic region

nervous system
• evident at E17.5
• folia in anterior lobe completely missing in almost all cases
• not restricted to anterior lobe, however, as all fissures appeared shallow
• layer organization normal, however
• differentiation and neural circuit formation fundamentally normal




Genotype
MGI:2653197
hm2
Allelic
Composition
Zic1tm1Jaru/Zic1tm1Jaru
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic1tm1Jaru mutation (2 available); any Zic1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death by 8 weeks of age

behavior/neurological
• less milk in stomach than littermate controls, authors suggest as a result of poor suckling
• authors attribute growth retardation to less milk ingestion
• extended period of time required to right self; sometimes completely unable to do so
• often lied on backs, forelimbs extended anteriorly and making irregular motions
• loss of coordinated movement of all 4 limbs
• dragged hindlimbs
• unable to walk a straight line
• most fell to one side

growth/size/body
• significantly smaller than littermate controls at P2, authors suggest due to poor suckling which resulted in decreased amounts of milk in stomach

skeleton
• in thoracic region

nervous system
• evident at E17.5
• folia in anterior lobe completely missing in almost all cases
• not restricted to anterior lobe, however, as all fissures appeared shallow
• layer organization normal, however
• differentiation and neural circuit formation fundamentally normal




Genotype
MGI:3716303
ht3
Allelic
Composition
Zic1tm1Jaru/Zic1+
Genetic
Background
B6.129S4-Zic1tm1Jaru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic1tm1Jaru mutation (2 available); any Zic1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants exhibit reduced horizontal motor activity

muscle
• mutants perform worse in a wire-hanging test than wild-type, however maximal grip strength is normal, indicating that muscle tone, but not maximal muscle strength, is reduced
• mutants show a slight, but significant reduction in ability to remain on a stationary rod, however show no difference in the retention time on a rotating rod

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Joubert syndrome DOID:0050777 OMIM:PS213300
J:72342




Genotype
MGI:3511206
ht4
Allelic
Composition
Zic1tm1Jaru/Zic1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic1tm1Jaru mutation (2 available); any Zic1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the anterior folia are disrupted in the vermis
• the vermis is slightly smaller compared to wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory