All Phenotypes Gpc3<Gt(Ex136)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpc3^Gt(Ex136)Byg
gene trap Ex136, BayGenomics
MGI:2156194

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpc3^Gt(Ex136)Byg/Gpc3^Gt(Ex136)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3826409
ht2	Gpc3^Gt(Ex136)Byg/Gpc3⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3849593
cx3	Bmp4^tm1Blh/Bmp4⁺ Gpc3^Gt(Ex136)Byg/Y	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3849594
ot4	Gpc3^Gt(Ex136)Byg/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:3849592

Allelic Composition	Gpc3^Gt(Ex136)Byg/Gpc3^Gt(Ex136)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:70273 )

growth/size/body

increased embryo size ( J:70273 )

• embryonic overgrowth

kidney cyst ( J:70273 )

renal/urinary system

kidney cyst ( J:70273 )

embryo

increased embryo size ( J:70273 )

• embryonic overgrowth

Allelic Composition	Gpc3^Gt(Ex136)Byg/Gpc3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal ventral body wall morphology ( J:64330 )

• ventral wall closure defects with incomplete penetrance

• usually results in small to moderate umbilical hernias

kidney medulla cyst ( J:64330 )

• medullary cystic dysplasia

increased body size ( J:64330 )

• males are 30% larger than controls

• females show intermediate growth properties

renal/urinary system

abnormal kidney medulla morphology ( J:64330 )

• medullary cystic dysplasia

kidney medulla cyst ( J:64330 )

• medullary cystic dysplasia

skeleton

split xiphoid process ( J:64330 )

• bifurcated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Simpson-Golabi-Behmel syndrome type 1		DOID:0060248	OMIM:312870	J:64330

Allelic Composition	Bmp4^tm1Blh/Bmp4⁺ Gpc3^Gt(Ex136)Byg/Y
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm1Blh mutation (2 available); any Bmp4 mutation (21 available)
Gpc3^Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:64330 )

• bifurcated 5th digits frequently seen on forelimbs

• ectopic triphalangeal duplications branching from the 5th metatarsal

• 66% show show similar branched bifurcation of the right 5th digit of the hind limb

skeleton

abnormal sternum ossification ( J:64330 )

• dual ossification centers along the length of the sternum

abnormal rib morphology ( J:64330 )

• deformed

rib fusion ( J:64330 )

Allelic Composition	Gpc3^Gt(Ex136)Byg/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:64330 )

• normal numbers of hemizygotes at E16.5

• hemizygotes reduced from 26% to 16% by weaning

growth/size/body

abnormal ventral body wall morphology ( J:64330 )

• ventral wall closure defects with incomplete penetrance

• usually results in small to moderate umbilical hernias

kidney medulla cyst ( J:64330 )

• medullary cystic dysplasia

increased body size ( J:64330 )

• males are 30% larger than controls

• females show intermediate growth properties

renal/urinary system

abnormal kidney medulla morphology ( J:64330 )

• medullary cystic dysplasia

kidney medulla cyst ( J:64330 )

• medullary cystic dysplasia

skeleton

split xiphoid process ( J:64330 )

• bifurcated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Simpson-Golabi-Behmel syndrome type 1		DOID:0060248	OMIM:312870	J:64330

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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